血浆miR-200c作为肺癌早期诊断的临床价值研究  

Clinical Value of Plasma miR-200c in Early Diagnosis of Lung Cancer

作　　者：王瑛琨[1] 贾冬冬[1] 刘琼[1] 窦宇红[1] 徐志康[1] 刘和录[1] WANG Yingkun;JIA Dongdong;LIU Qiong;DOU Yuhong;XU Zhikang;LIU Helu(Clinical Laboratory,Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University,Shenzhen, Guangdong 518125,China)

机构地区：[1]广州医科大学附属深圳沙井人民医院检验科,广东深圳518125

出　　处：《湖南中医药大学学报》2018年第1期40-42,共3页Journal of Hunan University of Chinese Medicine

基　　金：深圳市宝安区科技创新局社会公益项目(2014208)

摘　　要：目的分析血浆miR-200c的表达与肺癌患者临床病理特征的相关性,并探讨miR-200c能否作为肺癌早期诊断的潜在肿瘤标志物的可能性。方法收集55例肺癌患者和53例健康体检者,采用实时荧光定量PCR检测受检者血浆miR-200c的表达情况,对检测结果进行统计学分析。结果 miR-200c在肺癌患者组血浆中表达水平均高于正常对照组,差异有统计学意义(P<0.01)。受试者工作特征曲线显示miR-200c能够将肺癌与正常对照组区分出来(AUC=0.676)。结论血浆miR-200c的表达可能与肺癌的发生有关,提示miR-200c可作为特异性生物标志物对肺癌患者进行早期诊断的可能性。Objective To analyze the correlation between plasma miR-200c expression and clinicopathological features of lung cancer patients,and to explore the possibility of miR-200c as a potential tumor marker for early diagnosis of lung cancer.Methods Fifty lung cancer patients and fifty-three healthy subjects,the expression of miR-200c in plasma was detected by real-time fluorescent quantitative PCR,and the results were statistically analyzed.Results MiR-200c expression in lung cancer patients were higher than that in normal control group and the difference was statistically significant(P<0.01).The receiver operating characteristic curve showed that miR-200c expression was able to differentiate lung cancer from the normal control group(AUC=0.676).Conclusion The expression of miR-200c in plasma may be related to the occurrence of lung cancer,suggesting that miR-200c may be a specific biomarker in patients during early diagnosis.

关 键 词：肺癌 MIR-200C 实时荧光定量PCR 早期诊断 

分 类 号：R73-34[医药卫生—肿瘤] R734.2[医药卫生—临床医学]