谷氨酰胺对存在营养风险肝癌患者手术效果的影响  

Effect of glutamine on the surgical outcome of hepatic carcinoma patients with nutritional risk

作　　者：高静[1] 金辉[1] 封育瑾 徐天生[2] 毛春英[1] GAO Jing;JIN Hui;FENG Yujin;XU Tiansheng;MAO Chunying(Department of Nutrition,Quzhou People’s Hospital,Quzhou 324000,China)

机构地区：[1]衢州市人民医院营养科,浙江衢州324000 [2]衢州市人民医院外科,浙江衢州324000

出　　处：《全科医学临床与教育》2018年第2期175-177,共3页Clinical Education of General Practice

摘　　要：目的探索谷氨酰胺对存在营养风险的肝癌患者手术效果的影响。方法选取接受治疗的104例存在营养风险的肝癌患者为研究对象,按照随机数表法平均分成两组,观察组给予谷氨酰胺辅助治疗,对照组给予常规辅助治疗。比较两组患者的住院时间、康复时间,以及采集患者清晨空腹血液并检测前白蛋白、谷草转氨酶、白蛋白、胆碱酯酶、谷丙转氨酶指标水平,对两组患者治疗后出现的出血、合并感染、体质衰弱等并发症进行统计。结果观察组患者住院时间和康复时间均明显低于对照组患者,差异均有统计学意义(t分别=2.18、2.30,P均<0.05)。观察组患者的前白蛋白、白蛋白和胆碱酯酶水平均高于对照组,谷草转氨酶和谷丙转氨酶均低于对照组患者,差异均有统计学意义(t分别=2.28、2.14、2.42、2.24、2.18,P均<0.05)。观察组患者出血、合并感染、体质衰弱等并发症发生率明显低于对照组,差异有统计学有意义(χ2=5.02,P<0.05)。结论谷氨酰胺对存在营养风险的肝癌患者血清指标影响较大,能有效缩短住院时间及康复时间,降低并发症发生率。Objective To explore the effect of glutamine on the surgical effect of hepatic carcinoma patients with nutritional risk.Methods Totally 104 patients with nutritional risk of HCC patients were selected and randomly divided into two groups.The control group was given routine adjuvant therapy,and the observation group was given glutamine treatment.The hospitalization time and recovery time were compared,and the serum pre-albumin,cholinesterase,albumin,aspartate aminotransferase and alanine aminotransferase levels were collected,the complications such as bleeding,infection,physical weakness of the two groups were compared.Results The hospitalization time and recovery time in the observation group were significantly shorter than those in the control group(t=2.18,2.30,P<0.05).The pre-albumin,albumin and cholinesterase levels of the observation group were higher than the control group,while the aspartate aminotransferase and alanine aminotransferase were lower than that of control group,the differences were statistically significant(t=2.28,2.14,2.42,2.24,2.18,P<0.05).The incidence of complications such as bleeding,infection and physical weakness in the observation group was significantly lower than that in the control group(χ2=5.02,P<0.05).Conclusion Glutamine has a great influence on the serum indexes of patients with liver cancer,which can reduce the time of hospitalization and rehabilitation,and reduce the incidence of complications.

关 键 词：谷氨酰胺 营养风险 肝癌 住院时间 并发症 

分 类 号：R735.7[医药卫生—肿瘤]