氨氯地平在心衰治疗中对肿瘤坏死因子-α、白细胞介素-1,6的作用  

Effect of amlodipine on tumor necrosis factor-α, interleukin-1 and interleukin-6 in patients with heart failure

作　　者：宋浩明[1] 罗明[1] 邓南伟[1] 邹颂海[1] 邓兵[1] 刘健[1] 夏芝芸[1] 

机构地区：[1]同济大学附属同济医院心内科,上海200065

出　　处：《中国新药与临床杂志》2002年第11期661-663,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :探讨氨氯地平在心力衰竭 (心衰 )治疗中对细胞因子的作用。方法 :选择扩张型心肌病和缺血性心脏病心衰病人共 6 0例 ,随机分成常规组与氨氯地平组。常规组给予常规抗心衰治疗 ,氨氯地平组在常规治疗基础上加用氨氯地平 5mg ,po ,qd。同时建立正常组。检测肿瘤坏死因子 α(TNF α)、白细胞介素 1(IL 1)、白细胞介素 6 (IL 6 )。结果 :IL 1,IL 6 ,TNF α在心衰病人中分别达 (30±s 13) ,(99± 4 3)和 (2 4± 5 )ng·L- 1,较正常人[(6 .1± 1.7) ,(2 9± 8) ,(16± 5 )ng·L- 1]明显增高(P <0 .0 1)。治疗 6wk后 ,氨氯地平组病人较常规组IL 6 ,TNF α明显降低 ,分别为 (45± 2 4 )和 (17±5 ) ,(6 0± 31)和 (2 0± 4 )ng·L- 1(P <0 .0 1)。结论 :氨氯地平治疗心衰的作用之一可能在于降低细胞因子如IL 6和TNFAIM:To investigate the beneficial effect of amlodipine on a part of cytokines in treating heart failure. METHODS: Sixty patients with heart failure (thirty patients with idiopathic dilated cardiomyopathy and thirty patients with ischemic heart disease) were randomly divided into either routine treatment group or amlodipine treatment group. The routine treatment group was treated on a routine treatment the amlodipine treatment group was treated with amlodipine 5 mg, po, qd, besides the routine treatment. The TNF-α, IL-1 and IL-6 were measured. RESULTS:Plasma levels of IL-1, IL-6 and TNF-α,(30±13) ng·L -1,(99±43) ng·L -1 and (24±5) ng·L -1 respectively, were significantly elevated in heart failure patients than in healthy persons (P<0.01). After 6 wk treatment both IL-6 and TNF-α levels were (45±24) ng·L -1 and (17±5) ng·L -1, (60±31) ng·L -1 and (20±4) ng·L -1 which were significantly lower in amlodipine treatment group than those in routine treatment group (P< 0.01). CONCLUSION: One of the beneficial effects of amlodipine in CHF may be due to a reduction of cytokines such as IL-6, TNF-α.

关 键 词：氨氯地平 充血性心力衰竭 白细胞介素-1 白细胞介素-6 氨氯地平 肿瘤坏死因子-Α 

分 类 号：R541.61[医药卫生—心血管疾病] R972.1[医药卫生—内科学]