CD34、MMP-9、VEGF、PCNA在骨巨细胞瘤中的表达及临床意义  

Expression of CD34, MMP-9, VEGF, PCNA in giant cell tumor of bone and its clinical significance

作　　者：彭仲华[1] 梁亮科[2] PENG Zhonghua;LIANG Liangke(Department of Orthopaedics Traumatology,Sanshui Hospital Affiliated to Foshan TCM Hospital,Foshan,Guangdong 528100,China)

机构地区：[1]佛山市中医院三水医院骨伤科,广东528100 [2]佛山市中医院脊柱外科,528000

出　　处：《中国骨科临床与基础研究杂志》2017年第6期349-354,共6页Chinese Orthopaedic Journal of Clinical and Basic Research

摘　　要：目的探讨CD34、基质金属蛋白酶(MMP-9)、血管内皮生长因子(VEGF)、增殖细胞核抗原(PCNA)在骨巨细胞瘤(GCTB)组织中的表达及其临床意义,为GCTB的诊断与治疗提供临床依据。方法将2010年1月至2017年1月收治的80例GCTB手术患者纳入研究,采用免疫组化染色法检测GCTB组织中CD34、MMP-9、VEGF、PCNA的表达水平,分析其与GCTB患者年龄、性别、肿瘤大小、Jaffe分级以及预后之间的相关性。结果CD34、MMP-9、VEGF、PCNA的阳性表达与GCTB患者年龄、性别无明显相关性(P>0.05),与肿瘤大小、Jaffe分级、预后有显著相关性(P<0.05)。CD34与MMP-9、VEGF、PCNA的表达呈正相关(r=0.311,0.424,0.401;P=0.015,0.025,0.025)。结论 CD34、MMP-9、VEGF、PCNA在GCTB的发生发展中有重要作用,检测其表达水平对GCTB的诊断和预后具有一定的临床意义。Objective To explore the expression and clinical significance of CD34,matrix metalloproteinase(MMP)-9,vascular endothelial growth factor(VEGF),proliferating cell nuclear antigen(PCNA)in giant cell tumor of bone(GCTB),so as to provide clinical basis for the diagnosis and treatment of GCTB.Methods A total of 80 patients with GCTB treated from January 2010 to January 2017 were enrolled in this study.The expression of CD34,MMP-9,VEGF and PCNA in these patients was assayed by immunohistochemistry staining,and relations of expression of CD34,MMP-9,VEGF,PCNA with age,gender,tumor size,Jaffe grading and prognosis were analyzed.Results Positive expression of CD34,MMP-9,VEGF and PCNA showed no significant correlation with age or gender for GCTB patients,while levels of CD34,MMP-9,VEGF and PCNA were related to tumor size,Jaffe grading and prognosis;CD34 levels showed positive correlation to the expression of MMP-9,VEGF and PCNA(r=0.311,0.424,0.401;P=0.015,0.025,0.025).Conclusion CD34,MMP-9,VEGF,PCNA play important roles in the development and progression of GCTB,examination of expressions of these cytokines have certain clinical significances for the diagnosis and prognosis of GCTB.

关 键 词：巨细胞瘤 骨 细胞因子类 抗原 CD34 基质金属蛋白酶9 血管内皮生长因子类 增殖细胞核抗原 肿瘤复发 局部 预后 

分 类 号：R738[医药卫生—肿瘤]