371例结直肠息肉患者临床特征及其与粪便隐血和血CEA之间的关系  

Relationship between clinical features in 371 cases of colorectal polyps with fecal occult blood and CEA

作　　者：冯怡锟[1] 蒋玉涵[1] 刘维伟 胡桂明[1] 吴会芳[1] 王亚楠[3] 卢高峰[3] 崔静[3] 常佳[1] 任景丽[1] FENG Yikun;JIANG Yuhan;LIU Weiwei;HU Guiming;WU Huifang;WANG Yanan;LU Gaofeng;CUI Jing;CHANG Jia;REN Jingli(Department of Pathology,Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450014,China;Outpatient Department,Hebei Army Communications Training Base Hospital,Zhangjiakou,Hebei 075100,China;Department of Gastroenterology,Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450014,China)

机构地区：[1]郑州大学第二附属医院病理科,郑州450014 [2]河北陆军通信训练基地医院门诊部,河北张家口075100 [3]郑州大学第二附属医院消化内科,郑州450014

出　　处：《重庆医学》2018年第9期1183-1185,共3页Chongqing medicine

基　　金：河南省医学科技攻关普通项目(201503099)

摘　　要：目的研究371例结直肠息肉患者基本临床特征及其与粪便隐血和血癌胚抗原(CEA)之间的关系。方法回顾性分析371例结直肠息肉住院病例,探讨不同年龄患者在性别、息肉数量及息肉解剖学部位之间的关系,并通过1.5~3.0年的随访,分析粪便隐血及CEA与息肉癌变之间的关系。结果 371例结直肠息肉患者随着年龄增长,女性患者逐渐增多,单发息肉逐渐减少;由于年龄不同,息肉发生部位的差异有统计学意义(χ2=9.759,P=0.045);3个年龄段患者中息肉癌变者的分布差异均有统计学意义(χ2=5.138、4.107、13.153,P<0.05)。粪便隐血实验阳性及CEA异常升高者均随着年龄增长而逐渐增多(χ2=15.544、11.959,P<0.01);随着息肉个数增多,粪便隐血实验阳性的患者呈升高趋势(χ2=14.043,P=0.001);粪便隐血实验阳性及CEA异常升高的结直肠息肉患者其癌变率明显高于粪便隐血实验阴性及CEA在正常范围内的患者(χ2=40.165、43.249,P<0.01)。结论粪便隐血实验及CEA检测的结果对预防结直肠息肉癌变的随访具有一定的意义。Objective To investigate the basic clinical features in 371 cases of colorectal polyps and its relationship with fecal occult blood and carcinoembryonic antigen(CEA).Methods The retrospective analysis was performed on 371 inpatients with colorectal polyps.The relationship among gender,number of polyps and polyps anatomical site in different ages of patients was investigated,and the relationship between fecal occult blood and CEA with polyp canceration was analyzed by 1.5?3.0 years follow-up.Results Among 371 cases of colorectal polyps,the female patients were gradually increased and single polyp was gradually decreased along with the age increase;due to different ages,there was the statistically significant difference in the polyp locations(χ2=9.759,P=0.045);the distribution difference of the patients with polyp canceration among three age groups was statistically significant(χ2=5.138,4.107,13.153,P<0.05).The cases of fecal occult blood positive and CEA abnormal increase were gradually increased with age increasing(χ2=15.544,11.959,P<0.01);with the number of polyps increasing,the cases of fecal occult blood positive showed the increasing trend(χ2=14.043,P=0.001);the canceration rate in colorectal polyp cases of fecal occult blood positive and CEA abnormal increase was significantly higher than that in the cases of fecal occult blood negative and CEA normal range(χ2=40.165,43.249,all of P<0.001).Conclusion The fecal occult blood test and CEA detection results have a certain significance to the follow up for preventing colorectal polyps canceration.

关 键 词：结肠息肉 粪便隐血 癌胚抗原 

分 类 号：R735.34[医药卫生—肿瘤]