肿瘤早期筛查中血清TK1与CEA、AFP可信性研究  

The reliability of early screening of tumor markers including TK1,CEA and AFP in diagnosis of malignant tumors

作　　者：江小蓉[1] 王瑜[1] 王莎莎[1] JIANG Xiaorong;WANG Yu;WANG Shasha(Health Management Center,No.180 Hospital of PLA,Fujian,Quanzhou 362000,China)

机构地区：[1]中国人民解放军第180医院健康管理中心,福建省泉州市362000

出　　处：《河北医药》2018年第6期819-822,共4页Hebei Medical Journal

基　　金：中国健康促进基金会多中心课题(编号:CHPF 2014-TK1);泉州市科技计划重点项目(编号:2013Z56)

摘　　要：目的探讨血清胸苷激酶1(TK1)与癌胚抗原(CEA)、甲胎蛋白(AFP)在肿瘤早期筛查中的可信性研究。方法回顾性分析2009至2014年在中心进行常规体检的486 085人,对56 286人进行恶性肿瘤筛查。CEA和AFP的浓度通过电化学发光免疫分析法进行检测,STK1的浓度通过商用型增强化学发光点印迹分析法。结果恶性肿瘤发病率由48.3/10万增加到220.3/10万,发病率最高的3种恶性肿瘤分别为肝癌、宫颈癌、肺癌。STK1与肿瘤增殖速度相关,在检查恶性肿瘤和恶性肿瘤预后方面比CEA和AFP更灵敏。STK1也可作为预后生物标记物,可用于对恶性肿瘤患者术后10~40个月的随访,但是CEA和AFP不具有随访价值。结论 STK1是一种可用于在恶性肿瘤监测中发现恶性肿瘤患者的可信任的生物标记物。Objective To investigate the reliability of early screening of tumor markers including thymidine kinase 1(TK1),carcinoembryonic antigen(CEA)and alpha fetoprotein(AFP)in diagnosis of malignant tumors.Methods The data about 486,085 subjects who underwent routine medical examination in our Health Center from 2009 to 2014 were retrospectively analyzed,in whom 56,286 subjects received malignant tumor markers screening.The concentrations of CEA and AFP were dtected by electrochemiluminescence immunoassay,and STK1 levels were measured by commercial kit based on an enhanced chemiluminescence dot blot assay.Results The incidence rate of malignant tumors was increased from 48.3/100,000 to 220.3/100,000.The three kinds of tumors with higher incidence rate were liver cancer,cervical cancer and lung cancer,respectively.Moreover STK1 was correlated to tumor growth rate,which was more sensitive than CEA and AFP in diagnosis of malignant tumors and in evaluation of patient's prognosis.Besides STK1 was also regarded as a prognostic biomarker and could be used for postoperative follow up of patients for 10~40 months,but CEA and AFP had no significance of follow up.Conclusion STK1 is a reliable biomarker to discover malignant tumors in tumor screening.

关 键 词：血清胸苷激酶1 癌胚抗原 甲胎蛋白 体检筛查 恶性肿瘤 

分 类 号：R73[医药卫生—肿瘤]