炎症性肠病常见基因多态性  

Commonly Seen Gene Polymorphisms in Inflammatory Bowel Disease

作　　者：周文鹏 白爱平[1] ZHOU Wenpeng;BAI Aiping(Department of Gastroenterology,the First Affiliated Hospital of Nanchang University,Nanchang,330006)

机构地区：[1]南昌大学第一附属医院消化内科,330006

出　　处：《胃肠病学》2018年第3期177-180,共4页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(81470828;81770555)

摘　　要：炎症性肠病(IBD)包括溃疡性结肠炎(UC)和克罗恩病(CD),是一组肠道慢性复发性炎症性疾病。IBD的病因目前仍不清楚,其发病机制主要有遗传、免疫、环境、感染等因素参与。易感基因对IBD的发生、发展、临床表型乃至后续治疗具有重要影响,证明了遗传因素在IBD中的重要作用。本文对目前研究较多以及新近发现的IBD相关基因及其单核苷酸多态性(SNPs)作一综述。Inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohn’s disease(CD),is a group of chronic and relapsed inflammatory diseases of the intestinal tract.Genetic factors together with immunological,environmental and infectious factors contribute to the pathogenesis of IBD,however,the precise etiology is still uncertain.Susceptibility genes have great impact on the occurrence,development,clinical phenotypes,and even follow-up treatment of IBD,which indicates the significant roles of genetic factors in this disease.In this article,the well-studied and newly found genes related to IBD and their single nucleotide polymorphisms(SNPs)were reviewed.

关 键 词：炎症性肠病 结肠炎 溃疡性 CROHN病 多态性 单核苷酸 全基因组关联研究 

分 类 号：R574[医药卫生—消化系统]