某医院2014-2016年新生儿血小板减少症发生情况及影响因素分析  

Incidence and Influencing Factors of Neonatal Thrombocytopenia in a Hospital From 2014 to 2016

作　　者：卫晓慧[1] 王静[1] 白媛[2] WEI Xiaohui;WANG Jing;BAI Yuan(Department of Paediatrics,Affiliated Hospital of Yan'an University,Yan'an Shaanxi 716000,China)

机构地区：[1]延安大学附属医院儿科,陕西延安716000 [2]延安大学附属医院新生儿科

出　　处：《解放军预防医学杂志》2018年第1期97-99,102,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：陕西省卫生厅科研基金项目(No.2013JM4328)

摘　　要：目的调查新生儿血小板减少症(NTP)的发生情况及其影响因素,为NTP的预防和治疗提供依据。方法以本院2014年1月至2016年12月收治的574例新生儿为对象,回顾性分析其NTP发生情况,并采用Logistic多因素回归分析影响NTP患儿病情严重程度的危险因素。结果本组574例新生儿NTP的发生率为7.49%(43/574),其中早发型NTP患儿中存在肺部疾病、细菌性感染、临床出血、血小板计数<50×10~9/L、死亡例数明显低于晚发型NTP患儿,差异显著(P<0.05)。单因素分析结果显示,入院时体质量、胎龄、宫内生长迟缓、宫内感染、产妇表面血小板抗体、GPⅡb/Ⅲa与新生儿发生NTP密切相关。多因素Logistic回归分析结果显示,宫内感染、新生儿窒息、早产儿是影响新生儿发生NTP的高危因素。结论宫内感染、新生儿窒息、早产儿是影响新生儿发生NTP的高危因素,临床可以针对这些危险因素进行早期干预,以便有效预防NTP的发生。Objective To investigate the incidence and influencing factors of neonatal thrombocytopenia(NTP)and provide evidence for the prevention and treatment of NTP.Methods 574 newborns admitted to our hospital between January 2014 and December 2016 were selected as the subjects.The incidence of NTP was retrospectively analyzed.Logistic regression analysis was used to analyze the risk factors that affected the severity of NTP in children.Results The incidence of NTP in 574 newborns in this group was 7.49%(43/574).There were pulmonary diseases,bacterial infections,clinical bleeding and platelet count<50X10 in patients with early-onset NTP.The death toll was significantly lower than that of late-onset NTP patients(P<0.05).Univariate analysis showed that body mass,gestational age,intrauterine growth retardation,intrauterine infection,maternal surface platelet antibody and GPⅡb/Ⅲa were closely related to the occurrence of NTP in neonates.Multivariate logistic regression analysis showed that intrauterine infection,neonatal asphyxia and premature neonates were all risk factors for neonatal NTP.Conclusion Intrauterine infection,neonatal asphyxia and premature neonates are risk factors for neonatal NTP.Clinically,early intervention should be enforced according to these risk factors in order to effectively prevent the occurrence of NTP.

关 键 词：新生儿血小板减少症 发生情况 影响因素 

分 类 号：R73[医药卫生—肿瘤] R71[医药卫生—临床医学]