HIF-1α Glut-1表达与乳腺癌分化程度及分子亚型的关系  

The Relationship between the Expression of A and B and the Degree of Differentiation and Subtypes of Breast Cancer

作　　者：赵文明[1] 周炳娟[1] 李金梅[1] 陈雪[1] 张金库[1] ZHAO Wenming;ZHOU Bingjuan;LI Jinmei;Chen Xue;Zhang Jinku(Baoding First Central Hospital.Hebei Baoding 071000.China)

机构地区：[1]河北省保定市第一中心医院病理科,河北保定071000

出　　处：《河北医学》2018年第3期353-357,共5页Hebei Medicine

基　　金：河北省保定市科学研究与发展计划项目;(编号:16ZF110)

摘　　要：目的:探讨缺氧诱导因素-1α(HIF-1α)、葡萄糖转运蛋白1(Glut-1)表达与乳腺癌分化程度及分子亚型的关系。方法:采用免疫组化方法检测102例乳腺癌及60例癌旁正常组织的中HIF-1α、Glut-1蛋白表达情况,比较不同分化程度、分子分型乳腺癌组织中HIF-1α、Glut-1阳性表达率。结果:乳腺癌组织中HIF-1α、Glut-1蛋白阳性表达率分别为62.75%、68.63%高于癌旁正常组织的11.67%、16.67%,差异有统计学意义(P<0.05);高分化乳腺癌组织HIF-1α、Glut-1蛋白阳性表达率分别为34.78%、40.91%低于中分化的60.0%、68.88%和低分化的85.29%、88.24%(P<0.025),中分化低于低分化,差异有统计学意义(P<0.025);Luminal A型HIF-1α、Glut-1蛋白阳性表达率分别为46.67%、51.11%,与Luminal B型的54.55%、63.64%比较,差异无统计学意义(P>0.017),但Luminal A型、Luminal B型均低于HER-2过表达型的85.71%、92.86%和三阴型的90.48%、95.24%,差异有统计学意义(P<0.017),HER-2过表达型、三阴型比较,差异无统计学意义(P>0.017)。结论:乳腺癌患者HIF-1α、Glut-1呈高阳性表达,且不同分化程度、分子亚型的乳腺癌HIF-1α、Glut-1阳性表达存在差异。Objective:To investigate the relationship between the expression of-1-alpha(HIF-1-α),glucose transporter 1(Glut-1)and the degree of differentiation and molecular subtypes of breast cancer.Methods:Immunohistochemical method was used to detect the expression of HIF-1αand Glut-1 in 102 cases of breast cancer and 60 cases of adjacent normal tissues.The expression rates of HIF-1αand Glut-1 in breast cancer tissues with different degree of differentiation and molecular typing were compared.Results:The positive expression rates of HIF-1αand Glut-1 protein in breast cancer tissues were 62.75%and 68.63%,respectively,which were higher than those in 11.67%normal tissues.The difference was statistically significant(P<0.05).The positive expression rates of HIF-1αand Glut-1 protein in high differentiated breast cancer tissues were 34.78%and 40.91%,respectively,which were lower than those of moderately differentiated 60%,68.88%,and poorly differentiated 85.29%and 88.24%(P<0.025).The differentiation of moderately differentiated breast cancer was lower than that of poorly differentiated ones(P<0.025).There was no significant difference in positive expression rates of HIF-1αand Glut-1 protein between Luminal A type breast caner and Luminal B type breast caner(46.67%and 51.11%vs 54.55%and 63.64%)(P>0.017).However,the rates in Luminal A and Luminal B type breast cancer were all lower than those in tissues with over-expressed HER-2(85.71%,92.86%)and triple negative breast cancer(90.48%and 95.24%)(P<0.017).There was no significant difference between HER-2 overexpression type and three yin type(P>0.017).Conclusion:The expression of HIF-1αand Glut-1 in breast cancer patients is highly positive,and the positive expression of HIF-1 alpha and Glut-1 in different degree of differentiation and molecular subtype of breast cancer is different.

关 键 词：缺氧诱导因素-1α 葡萄糖转运蛋白1 乳腺癌 分子分级 分化程度 

分 类 号：R737.9[医药卫生—肿瘤]