血液OSC、OPG、NTX和尿液NTX的改变与乳腺癌骨转移治疗效果之间的关系研究  

The Relationship among the Changes of Serum OSC,OPG,NTX,Urine NTX with the Effect of Bone Metastasis Treatment in Breast Cancer

作　　者：邹燕鹏 孙宇 闻国权 张树平 钱朋飞 黎冠宏 刘丽红[2] ZOU Yan-peng;SUN Yu;WEN Guo-quan(Third People’s Hospital of Guangdong Huizhou City,Huizhou 516001,China)

机构地区：[1]广东省惠州市第三人民医院(广州医科大学附属惠州医院),广东惠州516001 [2]中国中医科学院中医药信息研究所

出　　处：《中国医学创新》2017年第31期8-11,共4页Medical Innovation of China

基　　金：惠州市科技计划项目(2014Y153)

摘　　要：目的:探讨乳腺癌骨转移患者血液中骨钙素(OSC)、骨保护素(OPG)、血液和尿液Ⅰ型胶原吡啶交联氨基末端肽(NTX)的改变与乳腺癌骨转移治疗效果之间的关系。方法:40例乳腺癌骨转移患者在接受解救化疗前和化疗3个月后检查血液中OSC、OPG、NTX和尿液NTX值,并同时进行骨CT增强和平扫检查,比较患者在治疗前与治疗后血液OSC、OPG、血液和尿液NTX值的差异,比较血液OSC、OPG、NTX和尿液NTX检查与骨CT增强和平扫检查在评估乳腺癌骨转移治疗效果的差异。结果:治疗后血液OSC、OPG、NTX和尿液NTX值与治疗前相比,均有所下降,比较差异均有统计学意义(P<0.001)。血液OSC、OPG、NTX和尿液NTX检查与骨CT增强与平扫检查有效与无效情况比较,差异均无统计学意义(P>0.05)。结论:乳腺癌骨转移的患者血液OSC、OPG、NTX和尿液NTX改变与乳腺癌骨转移治疗效具有一定关系,具有一定的临床意义。Objective:To investigate the relationship between the changes of serum OSC,OPG,NTX,urine NTX with the effect of bone metastasis treatment in breast cancer.Method:40 breast cancer patients with bone metastasis were checked the serum OSC,OPG,NTX and urine NTX before receiving chemotherapy and after 3 months chemotherapy,also at the same time enhance peace bone CT scan was checked,the patients’serum OSC,OPG,NTX,urine NTX before treatment and after treatment were compared,the check value difference between the serum OSC,OPG,NTX,urine NTX and CT enhanced scan in the evaluation the therapeutic effect of bone metastasis of breast cancer were compared.Result:After 3 moths treatment,the serum OSC,OPG,NTX and urine NTX were lower than before treatment,the differences were statistically significant(P<0.001).The test value of serum OSC,OPG,NTX and urine NTX compared with bone CT scan,the differences were not statistically significant(P>0.05).Conclusion:The effect of bone metastasis treatment in breast cancer has a certain relationship with the change of serum OSC,OPG,NTX and urine NTX,it has certain clinical significance.

关 键 词：乳腺癌 骨转移瘤 骨钙素 骨保护素 Ⅰ型胶原吡啶交联氨基末端肽 治疗效果 

分 类 号：R737.9[医药卫生—肿瘤]