不同年龄段与不同转移状态三阴性乳腺癌患者的临床和病理分析  

Clinical and Pathological Analysis of Triple-negative Breast Cancer Patients with Different Age and Different Metastatic Status

作　　者：戴素娟[1] 李俊韬[1] 张功亮[1] 郭广秀[1] DAI Sujuan;LI Juntao;ZHANG Gongliang(Ganzhou People’s Hospital,Ganzhou 341000,China)

机构地区：[1]江西省赣州市人民医院,江西赣州341000

出　　处：《中国医学创新》2017年第32期1-5,共5页Medical Innovation of China

基　　金：江西省科技厅项目(20111601)

摘　　要：目的:研究并探讨不同年龄段、不同转移状态三阴性乳腺癌患者的临床病理特征,为临床诊治三阴性乳腺癌提供借鉴和帮助。方法:选取赣州市人民医院2011年1月-2017年1月收治的100例三阴性乳腺癌患者作为研究对象,对其临床资料进行回顾性研究分析,根据患者的年龄段将其分为青年组(<35岁)、中年组(35~59岁)、老年组(≥60岁),同时根据患者术后转移状态将其分为转移组、无转移组,比较不同年龄段、不同转移状态患者的临床资料,对其临床病理特征进行总结分析。再根据临床资料中的患者术后5年预后情况,将其分为存活组、死亡组,比较两组患者的临床资料,对影响三阴性乳腺癌患者预后的危险因素进行单因素分析、多因素Logistics回归分析。结果:在不同年龄段患者中,青年组患者多选择保乳术治疗,而中年组和老年组患者多选择改良根治术治疗,三个年龄段患者的手术次数均以一次手术为主,病理类型多以浸润性导管癌为主,腋下多未出现淋巴结,术后多选择辅助化疗。在不同转移状态患者中,转移组患者与无转移患者在手术次数、肿瘤分期等方面比较,差异均有统计学(P<0.05)。经多因素Logistics回归分析发现,术后转移、肿瘤分期是影响三阴性乳腺癌患者预后的危险因素。结论:不同年龄段、不同转移状态三阴性乳腺癌患者其临床病理特征存在差异,不同年龄段患者的差异体现在手术方式选择上,不同转移状态患者的差异体现在手术次数和肿瘤分期方面,而其预后受到诸多因素干扰,还应采取积极干预措施。Objective:To study and explore the different age groups,different metastatic status of triple negative breast cancer patients with clinical and pathological features for the clinical diagnosis and treatment of triple negative breast cancer to provide reference and help.Method:A total of 100 patients with triple-negative breast cancer admitted in Ganzhou Municipal People’s Hospital from January 2011 to January 2017 were selected as the subjects.The clinical data of 100 patients with triple-negative breast cancer were analyzed retrospectively.The young group(35 years old),the middle-aged group(35-59 years old)and the elderly group(≥60 years).The patients were divided into two groups according to the postoperative metastasis status of the patients.Compared with different age groups,different metastatic status of patients with clinical data,the clinical and pathological characteristics of a summary analysis.According to the postoperative prognosis of patients in the case data,the patients were divided into survival group and death group.The clinical data of two groups were compared.The risk factors of the prognosis of patients with triple negative breast cancer were analyzed by univariate analysis and Logistics regression analysis.Result:Among the patients of different age groups,the patients in the young group were treated with breast conserving therapy.The patients in the middle-aged group and the elderly group were treated with modified radical mastectomy.The number of patients in the three age groups was mainly 1 operation,pathological type of invasive ductal carcinoma mainly under the armpit more than no lymph nodes,postoperative choice of adjuvant chemotherapy.There were significant differences in the number of operation and tumor staging between metastatic group and those of without metastasis group(P<0.05).Multivariate Logistic regression analysis showed that postoperative metastasis and tumor staging were the risk factors for the prognosis of patients with triple negative breast cancer.Conclusion:There a

关 键 词：三阴性乳腺癌 临床病理特征 预后 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]