CAPOX方案和SOX方案治疗进展期胃癌效果分析  

Efficacy analysis of CAPOX regimen and SOX regimen in the treatment of advanced gastric cancer

作　　者：刘晓梅[1] 王晓华[1] 周强[1] 罗中银 蒲高祥 罗文君[2] LIU Xiao-mei;WANG Xiao-hua;ZHOU Qiang;LUO Zhong-yin;PU Gao-xiang;LUO Wen-jun(Tumor Center,Suining Center Hospital Suining 629000,China;Department of General Surgery,Suining Center Hospital Suining 629000,China)

机构地区：[1]四川省遂宁市中心医院肿瘤中心,四川遂宁629000 [2]四川省遂宁市中心医院普外科,四川遂宁629000

出　　处：《中国现代普通外科进展》2017年第11期872-875,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的 :研究分析进展期胃癌应用CAPOX方案和SOX方案治疗的效果。方法 :2010年1月—2011年6月接受化疗的进展期胃癌患者140例,分成观察组(CAPOX方案)72例以及对照组(SOX方案)68例,两组均给予中心静脉置管术,并在化疗过程中针对性地予以止吐、保肝以及抑酸保护胃黏膜的相关药物。观察组应用CAPOX方案,对照组应用SOX方案,将21d作为1个化疗周期,共化疗2个周期后评定效果。结果:观察组有效率33.33%(24/72),与对照组的33.82%(23/68)差异无统计学意义(P>0.05)。观察组手足综合征发生率16.67%(12/72),明显高于对照组的2.94%(2/68)(P<0.05)。观察组不良反应的总发生率58.33%(42/72),与对照组的57.35%(39/68)差异无统计学意义(P>0.05)。1~5年生存率两组差异均无统计学意义(P>0.05)。两组治疗前后的CD3+、CD3+CD4+及CD4+/CD8+,差异均无统计学意义(P>0.05)。结论 :利用CAPOX方案以及SOX方案均可较好地治疗进展期胃癌,二者疗效及近远期生存率基本相当,且对患者的免疫功能影响无明显差别,但CAPOX方案可能存在较高的手足综合征发生概率。Objective:To study the effect of CAPOX regimen and SOX regimen in the treatment of advanced gastric cancer.Methods:140 patients with advanced gastric cancer who received chemotherapy from January 2010 to June 2011 in the hospital were enrolled in this study.The patients were divided into observation group(CAPOX regimen)72 cases and control group(SOX regimen)68 cases according to the different chemotherapy protocols,two groups were treated with central venous catheter,and in the course of chemotherapy for the given antiemetic,hepatoprotective and Acid suppression related drugs.The observation group was treated with CAPOX regimen,and the control group was treated with SOX regimen,and the 21d was used as the 1 chemotherapy cycle,and the effect was evaluated after 2 cycles of chemotherapy.Results:The effective rate of observation group was 33.33%(24/72),compared with the control group of 33.82%(23/68),the difference was not statistically significant(P>0.05).The incidence of hand foot syndrome in the observation group was 16.67%(12/72),was significantly higher than the control group of 2.94%(2/68),the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 58.33%(42/72),compared with the control group of 57.35%(39/68),the difference was not statistically significant(P>0.05).The 1 to 5 year survival rate of the observation group compared with the control group was not statistically significant(P>0.05).The two groups before and after treatment of CD3+,CD3+CD4+and CD3+/CD8+compared,the difference was not statistically significant(P>0.05).Conclusion:Using CAPOX scheme and the SOX regimen can be better in the treatment of advanced gastric cancer,curative effect and short and long term survival rate was almost equal and influence of immune function of patients with no significant difference,but CAPOX scheme may exist higher hand foot syndrome probability,it is worth clinical optic.

关 键 词：进展期胃癌 CAPOX方案 SOX方案 疗效 

分 类 号：R735.7[医药卫生—肿瘤]