结肠癌中p-mTOR、p-p70S6K的表达与临床病理意义  

Expression of p-m TOR and p-p70S6K in Colon Carcinoma and Its Relationship with Pathological Parameters

作　　者：赵溢斐 周逢强[2] 徐宏[2] 李新军[2] 郭丰瑞 ZHAO Yifei;ZHOU Fengqiang;XU Hong(Binzhou Medical University,Yantai 264003,China)

机构地区：[1]滨州医学院临床学院,山东烟台264003 [2]山东省滨州市人民医院

出　　处：《中国医学创新》2018年第2期46-49,共4页Medical Innovation of China

摘　　要：目的:探讨磷酸化哺乳动物雷帕霉素靶蛋白(p-m TOR)及其下游因子p-p70S6K在结肠癌中的表达情况,分析其与临床病理特征的关系。方法:应用免疫组织化学方法检测结肠癌组织、癌旁组织、正常结肠组织中p-m TOR、p-p70S6K的表达。结果:81例结肠癌组织中p-m TOR表达率为51.85%(42/81),显著高于正常结肠组织的21.74%(5/23)、癌旁组织35.80%(29/81),且p-m TOR的表达与TNM分期、结肠癌解剖位置相关(X^2=7.617、5.358,P<0.05)。p-p70S6K在结肠癌的表达率为72.84%(59/81),且与p-m TOR的表达呈正相关(r=0.356,P=0.001)。结论:p-m TOR、p-p70S6K蛋白在结肠癌组织中高表达,且与结肠癌的发生、解剖部位、TNM分期有关,可作为结肠癌诊断和预后判断的指标。Objective:To investigate the expression of mammalian target of rapamycin pamptomycin target protein(p-mTOR)and its downstream factor p-p70S6K in colonic carcinoma,and to analyze its relationship with clinicopathological features.Method:The p-mTOR and p-p70S6K expression was detected in normal,adjacent,and colonic carcinoma tissues using immunohistochemical method.Result:The expression rate of p-mTOR in 81 cases of colonic carcinoma was 51.85%(42/81),which was significantly higher than that in normal tissues(21.74%,5/23)or adjacent tissues(35.80%,29/81),and the expression of p-mTOR was correlated with TNM stage and colonic carcinoma location(字2=7.617,5.358,P<0.05).The expression rate of p-p70S6K in colonic carcinoma was 72.84%(59/81)and was positively correlated with the expression of p-mTOR(r=0.356,P=0.001).Conclusion:p-mTOR,p-p70S6K protein is highly expressed in colorectal cancer tissues and is related to the occurrence,anatomical site and TNM staging of colon cancer,which can be used as an index for the diagnosis and prognosis of colon cancer.

关 键 词：P-MTOR p-p70S6K PI3K/AKT通路 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]