促进心肌干细胞向心肌细胞分化的策略  

Strategies for promoting the differentiation of cardiac stem cells into cardiomyocytes

作　　者：汪蕾[1] 陈旭翔[1] 伍权华[1] 吴浩[1] 龙会宝[1] 侯婧瑛[1] 王彤[1] Wang Lei;Chen Xu-xiang;Wu Quan-hua;Wu Hao;Long Hui-bao;Hou Jing-ying;Wang Tong(Department of Emergency,Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou 510120,Guangdong Province,China)

机构地区：[1]中山大学孙逸仙纪念医院急诊科,广东省广州市510120

出　　处：《中国组织工程研究》2018年第5期774-780,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81700242)"lncRNA-H19/miR-199a-5p/VEGF通路在apelin促进MSCs生存和血管再生改善心梗后心衰中的作用及机制研究";广东省科技计划项目(2017A020215176)"Apelin激活PI3K/AKT经lncRNA-H19/miR-199a-5p/VEGF途径促进MSCs生存和血管再生改善心肌梗死后心力衰竭机制研究";广东省医学科研基金(A2016264)"心肌干细胞经由HIF-1α/Apelin/APJ/ACE2通路下调ANGII改善心肌梗死大鼠心电生理学稳定性的机制研究";广东省医学科研基金(A2017001)"Apelin经PI3K/AKT/miR-199a-5p/VEGF通路促进骨髓间充质干细胞生存和血管再生改善心肌梗死后心力衰竭机制研究"~~

摘　　要：背景:近年研究表明心脏内存在内源性的心肌干细胞,可以修复受损心肌,使心肌再生。目的:综述目前能够提高心肌干细胞分化的方法。方法:应用计算机检索Pub Med数据库中近10年有关心肌干细胞分化的文献,检索词为"cardiac stem cells,cardiac progenitor cells,differentiation",选择以提高心肌干细胞分化为主题的文章,最终选取代表性英文文献64篇。结果与结论:通过导入细胞因子,micro-RNA以及一些物理与化学的方法诱导心肌干细胞向心肌细胞分化,从而显著提高了心肌干细胞治疗心肌梗死的效率。BACKGROUND:In recent years,it has shown that there exist some endogenous cardiac stem cells in the heart.What has been confirmed is that this kind of cells can differentiate into cardiomyocytes to repair the damaged myocardium and improve the cardiac function.OBJECTIVE:To review the current methods of promoting the differentiation of cardiac stem cells into cardiomyocytes.METHODS:PubMed database was searched by computer for articles addressing the differentiation of cardiac stem cells in the last 10 years,using the keywords of“cardiac stem cells,cardiac progenitor cells,differentiation”.Finally,64 English articles we re included in result analysis.RESULTS AND CONCLUSION:Recent studies have shown that the differentiation efficiency of cardiac stem cells can be promoted in vivo by introducing cytokines,micro-RNA,and some physicochemical methods,which consequently enhances the therapeutic efficacy of cardiac stem cell transplantation for myocardial infarction.

关 键 词：心肌干细胞 心肌细胞 干细胞 心肌梗死 分化 国家自然科学基金 

分 类 号：R394.2[医药卫生—医学遗传学]