羊水栓塞治疗及人羊膜间充质干细胞防治的可行性  

A feasible study of human amniotic mesenchymal stem cells for prevention and treatment of amniotic fluid embolism

作　　者：张莉[1] 王玉丹 谢成明[2] 余舰[1] Zhang Li;Wang Yu-dan;Xie Cheng-ming;Yu Jian(Center of Forensic Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China;Zunyi Medical University,Zunyi 563000,Guizhou Province,China)

机构地区：[1]遵义医学院附属医院司法医学鉴定中心,贵州省遵义市563000 [2]遵义医学院,贵州省遵义市563000

出　　处：《中国组织工程研究》2018年第5期781-786,共6页Chinese Journal of Tissue Engineering Research

基　　金：贵州省科学技术基金资助项目(黔科合J字[2012]2358)~~

摘　　要：背景:目前羊水栓塞存在两大难题亟待解决,一是找出诊断羊水栓塞的特异性指标,二是对羊水栓塞进行预防和治疗。现阶段尚无有效治疗方法,只能对临床表现对症治疗,治疗效果差,死亡率居高不下。目的:探讨人羊膜间充质干细胞防治羊水栓塞的可行性。方法:在CNKI与Pub Med数据库检索相关文献,中文关键词为"羊水栓塞"、"人羊膜间充质干细胞",英文关键词为"amniotic fluid embolism"、"human amniotic mesenchymal stem cells",对纳入43篇文献进行归纳总结。结果与结论:从羊水栓塞发病机制免疫炎症反应角度出发,使妊娠免疫学与移植生物学相联系,提出人羊膜间充质干细胞在理论上可调节羊水栓塞发生时产妇的免疫系统,并减轻羊水栓塞导致的急性肺损伤,为羊水栓塞防治提供了新的研究思路。BACKGROUND:Currently,there are two difficult problems concerning amniotic fluid embolism.One is to find out the specific indicators for diagnosis of amniotic fluid embolism and the other is to prevent and treat amniotic fluid embolism.However,there are yet no effective treatments,and symptomatic treatment for clinical manifestations is the only treatment for amniotic fluid embolism,which has poor outcomes and leads to a high mortality rate.OBJECTIVE:To explore the feasibility of human amniotic mesenchymal stem cells to prevent and treat amniotic fluid embolism.METHODS:CNKI and PubMed data bases were searched for relevant articles with the key words of“amniotic fluid embolism,human amniotic mesenchymal stem cells”in Chinese and English,respectively.And finally 43 articles were included and summarized.RESULTS AND CONCLUSION:From the point of view of the pathogenesis of immune inflammatory reaction of amniotic fluid embolism,the immunology of pregnancy is related to transplantation biology.It is theoretically suggested that human amniotic mesenchymal stem cells can prevent and treat amniotic fluid embolism,regulate the immune system of the puerpera with amniotic fluid embolism,and reduce acute lung injury caused by amniotic fluid embolism.This method provides a new perspective for research on the prevention and treatment of amniotic fluid embolism.

关 键 词：羊水栓塞 干细胞 人羊膜间充质干细胞 炎症反应 急性肺损伤 综述 治疗 

分 类 号：R394.2[医药卫生—医学遗传学]