红景天苷对不同运动状态下小鼠糖、脂肪及蛋白质代谢的影响  

Effects of salidroside on glucose,fat and protein metabolism in mice under different motion status

作　　者：豆瑞 马莉[1] 郭晓冬[1] 王莹[2] 裴素萍[2] DOU Rui;MA Li;GUO Xiao-dong;WANG Ying;PEI Su-ping(Dept.of Clinical Nutrition,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Dept.of Clinical Nutrition,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院营养科,上海200437 [2]第二军医大学附属长海医院营养科,上海200433

出　　处：《同济大学学报（医学版）》2018年第1期59-63,共5页Journal of Tongji University(Medical Science)

摘　　要：目的探讨红景天苷(SDS)对不同运动状态下小鼠糖、脂肪及蛋白质代谢的影响。方法根据体质量,把32只雄性昆明小鼠随机分为4组:运动组、对照组、SDS+运动组及SDS组。SDS组及SDS+运动组灌胃180 mg/(kg·d)的SDS,对照组及运动组灌胃同体积[0.02 m L/(g·d)]的蒸馏水,连续灌胃15 d。运动组及SDS+运动组在末次灌胃30 min后进行无负重游泳120 min,之后处死取材。检测肌糖原、肝糖原、血糖、血浆游离脂肪酸、总胆固醇、血三酰甘油、球蛋白、白蛋白、血浆总蛋白及血浆氨基酸谱。结果 SDS能增加运动后小鼠肝、肌糖原储备(P<0.01),从而延缓糖原的耗竭,维持血糖稳定;降低小鼠的血脂、血游离脂肪酸(P<0.05),促进脂肪利用;降低色氨酸/支链氨基酸值(P<0.01),降低运动组小鼠的血浆色氨酸和总氨基酸浓度(P<0.01),影响氨基酸的代谢。结论 SDS对不同运动状态下小鼠的糖、脂肪及氨基酸代谢有显著影响。Objective To investigate the effects of salidroside(SDS)on glucose,fat and protein metabolism in mice under different motion status.Methods Thirty-two male Kunming mice were randomly divided into 4 groups:training group,control group,SDS+training group and SDS group.The mice in the SDS group and SDS+training group were given 180 mg/(kg·d)SDS and the mice in control group and training group were given distilled water for 15 days.After the last administration,the mice in the training group and SDS+training group were forced to swim for 120 min without load.Finally all the mice were sacrificed.The muscle glycogen,liver glycogen,blood glucose,free fatty acid(FFA),plasma contents of total cholesterol(TC),triglyceride(TG),globulin(Glob),albumin(ALB),total protein(TP)and free amino acids were measured in all groups.Results Salidroside increased the liver,muscle glycogen reserves(P<0.01),delayed the decline of glycogen,maintained the blood sugar.It reduced the blood lipid,FFA(P<0.05),promoted the use of fat.It decreased the ratio of Trp/BCAA(P<0.01),the plasma concentrations of tryptophan and total amino acidin training group(P<0.01),affecting the metabolism of albuminolysis.Conclusion Salidroside has a significant effect on glucose,fat and amino acid metabolism in mice with different motion states.

关 键 词：红景天苷 物质代谢 疲劳 

分 类 号：R151[医药卫生—营养与食品卫生学]