肝硬化门脉高压性胃病进展的临床相关因素分析  

Risk factors for progression of portal hypertension gastropathy in patients with liver cirrhosis

作　　者：吕暘 陈豪[2] 黄岩 刘宁 夏玉敬[1] 周莹群[1] LYU Yang;CHEN Hao;HUANG Yan;LIU Ning;XIA Yu-jing;ZHOU Ying-qun(Dept.of Gastroenterology,Tenth People s Hospital,Tongji University,Shanghai 200072,China;Dept.of Gastroenterology,Qidong People s Hospital,Qidong 226200,Jiangsu Province,China)

机构地区：[1]同济大学附属第十人民医院消化内科,上海200072 [2]江苏省启东市人民医院消化内科,江苏226200

出　　处：《同济大学学报（医学版）》2018年第1期114-117,共4页Journal of Tongji University(Medical Science)

摘　　要：目的探讨影响肝硬化患者门脉高压性胃病(portal hypertension gastropathy,PHG)的临床特点及其进展的相关因素。方法回顾性分析61例肝硬化患者内镜检查结果。将患者分成PHG组(43例)和非PHG组(18例),比较分析两组年龄、性别、白蛋白、肝功能、总胆红素、肌酐水平、门静脉内径宽度、凝血功能。探讨并发PHG及食管静脉曲张(esophageal varices,EV)等的情况。结果 61例肝硬化患者中,EV 60例(98.3%),PHG 43例(70.5%)。PHG的发病率和严重程度随着EV的严重程度及肝功能分级的增加呈上升趋势(P<0.05),且EV程度是PHG的独立危险因素(OR=2.726,95%CI:1.140~6.519)。结论肝硬化患者PHG发病率及严重程度与EV严重程度及肝功能分级升高及呈正相关。Objective To analyze the risk factors for the progression of portal hypertension gastropathy(PHG)in patients with liver cirrhosis.Methods Sixty-one patients with liver cirrhosis were enrolled in the study,including 43 cases with PHG(PHG group)and 18 cases without PHG(non-PHG group).The relationship of age,gender,liver function,portal vein diameter,albumin,total bilirubin,prothrombin time and other clinical data with PHG was analyzed with univariate and multivariate Logistic regression.Results There were 60 cases(98.3%)of esophageal varices(EV)in this series,while all PHG patients had EV.The severity of EV and the Child-Pugh grade of liver function in PHG group were higher than those in non-PHG group(P<0.05).Multivariate Logistic regression showed that the severity of esophageal varices was an independent risk factor for portal hypertensive gastropathy(OR=2.726,95%CI:1.140 6.519,P=0.024).Conclusion The incidence and severity of portal hypertensive gastropathy is correlated with the severity of esophageal varices in patients with liver cirrhosis.

关 键 词：门脉高压性胃病 食管静脉曲张 肝功能 相关因素 

分 类 号：R573[医药卫生—消化系统]