血清缺血修饰白蛋白联合D-二聚体检测在诊断缺血性结肠炎中的价值  

The value of detection of serum ischemic modified albumin combined with D-two polymer in the ischemic colitis

作　　者：隆维东 龙结根[2] 朱艮苗[1] 黄冬悦[3] 向姝[4] LONG Wei dong;LONG Jie gen;ZHU Gen miao;HUANG Dong yue;XIANG Shu(Department of Clinical Laboratory,Banan District People's Hospital in Chongqing,Chongqing 401320,China;Department of General Surgery,Banan District People's Hospital in Chongqing,Chongqing 401320,China;Department of Clinical Laboratory,Huaxi Second Hospital of Sichuan University,Chongqing 610041,China;Endocrinology Department,Banan District People's Hospital in Chongqing,Chongqing 401320,China)

机构地区：[1]重庆市巴南区人民医院检验科,重庆401320 [2]重庆市巴南区人民医院普通外科,重庆401320 [3]四川大学华西第二医院检验科,重庆610041 [4]重庆市巴南区人民医院内分泌科,重庆401320

出　　处：《海南医学院学报》2018年第3期308-310,314,共4页Journal of Hainan Medical University

基　　金：国家高技术研究发展计划(863计划)(2015AA020110)~~

摘　　要：目的:探讨血清缺血修饰白蛋白联合D-二聚体检测在诊断缺血性结肠炎中的价值,为临床早期诊断缺血性结肠炎提供简单、敏感的诊断方法。方法:选取我院收治疑似缺血性结肠炎患者58例,其中经结肠镜诊断缺血性结肠炎患者38例,非缺血性结肠炎患者20例,同时选取正常对照者38例,检测各组间血清缺血修饰白蛋白和D-二聚体水平。结果:缺血性结肠炎患者IMA、D-二聚体水平明显高于非缺血性结肠炎患者与正常患者(P<0.05);非缺血性结肠炎患者IMA、D-二聚体水平与正常组患者相比差异无统计学意义(P>0.05);在缺血性结肠炎患者中多段病变组D-二聚体水平明显高于单段病变组(P<0.05),而IMA水平虽高于单段病变组,但差异无统计学意义(P>0.05);IMA联合D-二聚体诊断IC的敏感度为0.84,特异度为0.75,ROC曲线下面积为0.95,明显高于各单项检测。结论:IMA联合D-二聚体检测可提高诊断缺血性结肠炎的敏感度和特异度。Objective:To analyze the value of IMA combined with D two polymer in the diagnosis of IC,and provide a method in diagnosis of ischemic colitis early with simple and sensitive.Methods A total of 58 patinets were suspected IC from March 2015 to March 2017 at our hospital,in 58 cases of patients with ischemic colitis.38 patients with IC and 20 patients with no IC through colonoscopic,meanwhile select 38 patients of normal,to detection the level of IMA and D two polymer in every groups.Results The level of IMA and D two polymer in IC is highter than the no IC and the patients of normal(P<0.05);there was no significantly difference between the no IC and the patients of normal(P>0.05);the level of D two polymer in the group of multisegment lesion is highter than the group of Single lesion(P<0.05);also the level of IMA in the group of multisegment lesion is highter than the group of Single lesion,but there was no significantly difference(P>0.05);the sensitivity and specificity of combined IMA and D two polymer is 0.84 and 0.75,the area under the curve is 0.95,and higher than the single test obviously.Conclusion The detection of IMA combined with D two polymer can improve the sensitivity and specificity in the diagnosis of ischemic colitis.

关 键 词：血清缺血修饰白蛋白 D二聚体 缺血性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]