高血压脑出血患者治疗中依达拉奉对脑血管血液动力学参数及神经功能的影响分析  

Analyze the Effect of Edaravone on Cerebrovascular Hemodynamic Parameters and Neurological Function in Patients with Hypertensive Intracerebral Hemorrhage

作　　者：蒋一杨 JIANG Yiyang(First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)

机构地区：[1]锦州医科大学附属第一医院,辽宁锦州121001

出　　处：《中国医学创新》2018年第4期69-72,共4页Medical Innovation of China

摘　　要：目的:分析高血压脑出血患者治疗中依达拉奉对脑血管血液动力学参数及神经功能的影响。方法:选取2012年1月-2016年4月203例高血压脑出血患者,将患者分为对照组(n=94)和研究组(n=109)。对照组患者采用常规治疗方法,研究组患者采用依达拉奉治疗,对比两组患者脑血管动力参数脑血管平均流速(Vmean)、脑血管平均流量(Qmean)、血管外周阻力(R)、动态阻力(DR)及临界压(CP),神经功能量表mRS、SSS评分和临床疗效。结果:两组患者治疗前脑血管动力参数Vmean、Qmean、R、DR及CP等比较,差异均无统计学意义(P>0.05)。治疗后研究组患者CP、DR和R均低于对照组,Qmean和Vmean均高于对照组,比较差异均有统计学意义(P<0.05);且研究组患者治疗后脑血管动力参数Vmean、Qmean、R、DR及CP均明显优于治疗前,比较差异均有统计学意义(P<0.05)。两组患者治疗前mRS、SSS评分对比差异均无统计学意义(P>0.05),两组患者治疗后mRS、SSS评分与各自治疗前对比差异均有统计学意义(P<0.05)。研究组患者mRS评分明显低于对照组,SSS评分明显高于对照组,比较差异均有统计学意义(P<0.05)。结论:高血压脑出血患者采用依达拉奉治疗可改善患者脑血管功能,改善脑血管动力学参数,神经功能得到提高,提高临床疗效。Objective:To analyze the effect of Edaravone on hemodynamic parameters and neurological function in patients with hypertensive intracerebral hemorrhage.Method:A total of 203 patients with hypertensive intracerebral hemorrhage were selected from January 2012 to April 2016 in this study.They were divided into the control group(n=94)and study group(n=109).The control group was treated with regular treatment.The study group was treated with Edaravone.The cerebrovascular parameters Vmean,Qmean,R,DR and CP,neurological function scale mRS,SSS score and clinical curative effects of two groups were compared.Result:There were no significant differences in Veman,Qmean,R,DR and CP between the two groups before treatment(P>0.05).After treatment,the hemodynamics parameters of CP,DR and R were lower than those in the control group,Qmean and Vmean were higher than those in the control group,the differences were statistical significance(P<0.05);and the cerebrovascular parameters of Vmean,Qmean,R,DR and CP were significantly better than those before treatment in the study group,and the differences were statistically significant(P<0.05).There were no significant differences in mRS and SSS scores between the two groups before treatment(P>0.05).The mRS and SSS scores of the two groups were statistically different from those before treatment(P<0.05).The mRS score of the study group was significantly lower than that of the control group,and the SSS score was significantly higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion:The treatment of Edaravone in patients with hypertensive intracerebral hemorrhage can improve the cerebrovascular function,improve the cerebrovascular parameters,the neurological function and the clinical curative effect.

关 键 词：脑出血 依达拉奉 血流动力学 神经功能 

分 类 号：R743.34[医药卫生—神经病学与精神病学]