单核细胞趋化蛋白-1在原发性急性闭角型青光眼患者房水中的表达及其与小梁切除术预后的关系  

Expression of monocyte chemoattractant protein-1 in aqueous humor of patients with primary acute angle-closure glaucoma and its association with the patients' prognosis after trabeculectomy

作　　者：王红霞 李永华[1] 高秀华[1] WANG Hong Xia;LI Yong Hua;GAO Xiu Hua(From the Department of Ophthalmology,the Affiliated Hospital of Jining Medical University,Jining 272100,Shandong Province,China)

机构地区：[1]济宁医学院附属医院眼科,山东省济宁市272100

出　　处：《眼科新进展》2018年第3期242-246,共5页Recent Advances in Ophthalmology

基　　金：山东青年科研基金(编号:2010G0020250)~~

摘　　要：目的观察原发性急性闭角型青光眼(primary acute angle-closure glaucoma,APACG)患者房水中单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)的浓度,并探讨它与小梁切除术预后的关系。方法回顾性病例对照研究。纳入小梁切除术失败的APACG患者19例作为病例组,57例年龄、性别匹配的小梁切除术成功的APACG患者作为对照组。APACG患者小梁切除术术前收集房水,用酶联免疫吸附试验检测两组患者房水中MCP-1浓度。采用单因素以及多因素logistic回归分析小梁切除术失败的危险因素。结果病例组患者房水中MCP-1的浓度为(5688.04±2099.99)ng·L^(-1),对照组为(2077.57±568.44)ng·L^(-1),病例组房水中MCP-1的浓度明显高于对照组,两组相比差异有统计学意义(P<0.001)。logistic回归分析显示,术前房水中MCP-1浓度(OR=1.005;95%CI=1.001~1.008)以及患者小梁切除术后浅前房发生(OR=31.430;95%CI=1.577~57.350)是小梁切除术失败的独立危险因素。结论术后1 a随访时小梁切除手术失败的APACG患者房水中MCP-1的浓度明显高于小梁切除手术成功的患者。APACG患者房水中MCP-1浓度是小梁切除手术失败的独立危险因素。ObjectiveTo measure the levels of monocyte chemoattractant protein 1(MCP 1)in the aqueous humor of patients with acute primary angle closure glaucoma(APACG),and its correlation with the patients’prognosis after trabeculectomy.MethodsThis retrospective case control study included 19 patients with APACG who experienced a failed trabeculectomy(case group)and 57 age and sex matched patients with APAGG who underwent successful trabeculectomy(control group).Aqueous humor was collected before trabeculectomy for the detection of MCP 1 levels in the both groups by enzyme linked immunosorbent assay.And finally,logistic regression analysis was applied to assess the risk factors for failed trabeculectomy.ResultsThe MCP 1 concentration in aqueous humor was(5688.04±2099.99)ng·L-1 in the case group and(2077.57±568.44)ng·L-1 in the control group,and the difference between both groups were significant(P<0.001).Logistic regression analysis revealed MCP 1 level(OR=1 005;95%CI=1.001-1.008)and a shallow anterior chamber after surgery(OR=31 430;95%CI=1.577-57.350)were the independent risk factors for failed trabeculectomy procedures.ConclusionMCP 1 levels in aqueous humor are higher in APACG eyes with failed trabeculectomy than those with successful one during 1 year follow up,so MCP 1 level is considered as an independent risk factor for failed trabeculectomy.

关 键 词：原发性急性闭角型青光眼 单核细胞趋化蛋白-1 危险因素 

分 类 号：R775.2[医药卫生—眼科]