原发性慢性闭角型青光眼黄斑区内层和外层视网膜厚度变化  

Change of the thickness of macular inner and outer retina in patients with chronic primary angle-closure glaucoma

作　　者：杨楠[1] 马英慧[1] 崔秀成[1] 董志军[1] 许雪妹[1] YANG Nan;MA Ying Hui;CUI Xiu Cheng;DONG Zhi Jun;XU Xue Mei(From the Department of Ophthalmology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei Province,China)

机构地区：[1]承德医学院附属医院眼科,河北省承德市067000

出　　处：《眼科新进展》2018年第3期277-280,共4页Recent Advances in Ophthalmology

摘　　要：目的观察慢性原发性闭角型青光眼(chronic primary angle-closure glaucoma,CPACG)黄斑区内层、外层视网膜厚度的变化特征。方法选取我院就诊的CPACG患者58例(58眼)为研究对象,按病情严重程度分3组,即早期CPACG组14例,进展期CPACG组23例,晚期CPACG组21例,同时选择23名(23眼)健康无眼疾志愿者作为对照组,应用RTVue-100频域光学相干断层扫描仪对其黄斑区中心凹、近中心凹、旁中心凹处内层、外层视网膜厚度进行检测。结果对照组、早期CPACG组、进展期CPACG组、晚期CPACG组黄斑区近中心凹处内层视网膜厚度分别为(135.62±2.96)μm、(124.21±6.47)μm、(119.74±10.67)μm、(94.95±11.24)μm,黄斑区内层视网膜近中心凹处早期CPACG组、进展期CPACG组、晚期CPACG组与对照组相比厚度均明显变薄,差异均有统计学意义(均为P<0.05),且早期CPACG组、进展期CPACG组与晚期CPACG组两两之间比较差异均有统计学意义(均为P<0.05)。黄斑区外层视网膜中心凹、近中心凹、旁中心凹处晚期CPACG组与对照组相比厚度均明显变薄,差异均有统计学意义(均为P<0.05)。结论晚期CPACG患者表现为黄斑区内层、外层视网膜厚度弥漫性变薄,早期患者仅有黄斑区内层视网膜近中心凹处厚度变薄的特点。ObjectiveTo measure the thickness of macular inner and outer retina of chronic primary angle closure glaucoma(CPACG)and observe its features.MethodsTogether 58 patients(58 eyes)including 14 patients with early CPACG,23 patients with moderate CPACG and 21 patients with severe CPACG were recruited as early CPACG group,moderate CPACG and severe CPACG group,respectively;additional 23 healthy volunteers were chosen as controls.The thickness of macular inner and outer retina at all parts were measured by RTVue 100 SD OCT.ResultsThe macular inner retinal thicknesses in fovea were(135.62±2.96)μm,(124.21±6.47)μm,(119.74±10.67)μm and(94.95±11.24)μm in the control group,early CPACG,moderate CPACG and severe CPACG group,respectively.The thicknesses of macular inner retina of fovea were significantly decreased in the early CPACG group,moderate CPACG group and severe CPACG group when compared with the control group(all P<0.05).There were also significant differences between early CPACG group and moderate CPACG group,severe CPACG group and moderate CPACG group and early CPACG group and severe CPACG group(all P<0.05).The thicknesses of macular outer retina of fovea,parafovea and perifovea were significantly decreased in the severe CPACG group compared with the control group(all P<0.05).ConclusionThe thickness of macular inner and outer retina are decreased at all parts in patients with the severe CPACG.The macular inner retinal thickness only in the fovea is thinner in the patients with the early CPACG.

关 键 词：频域光学相干断层扫描 慢性原发性闭角型青光眼 黄斑区视网膜 

分 类 号：R775.2[医药卫生—眼科]