信号转导通路与肝细胞癌发生机制的研究进展  

Advance of Research on Signaling Pathways and Hepatocellular Carcinoma

作　　者：高艳芳[1] 欧阳璐[1] 胡恭华[1] GAO Yan-fang;OUYANG Lu;HU Gong-hua(Dept.of Preventive Medicine,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院预防医学系,江西赣州341000

出　　处：《赣南医学院学报》2018年第1期80-83,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(81260434;81060241);江西省自然科学基金项目(20132BAB205071;20114BAB205041);江西省教育厅科学技术研究项目(GJJ13689;GJJ14699);江西省卫生厅科技计划项目(20113133)

摘　　要：肝细胞癌(HCC)是我国常见的恶性肿瘤之一,发病分子机制主要涉及某些癌症相关基因的遗传学、表观遗传学改变以及信号转导通路的改变。本文重点就参与HCC发病的主要信号途径,包括P53/ARF、RB/INK4A、Wnt/β-catenin、Ras、PI3K/Akt/mTOR、IGF及HGF/c-Met途径作一综述。Hepatocellular carcinoma(HCC)is the most common malignant tumors in China.The molecular mechanism of pathogenesis mainly involves some cancer-related gene genetics,epigenetic changes and the change of signal transduction pathways.Special emphasis in this review is given to the major signaling pathways involved in the pathogenesis of HCC,including P53/ARF,RB/INK4A,Wnt/β-catenin,Ras,PI3K/Akt/mTOR,IGF and HGF/c-Met.

关 键 词：肝细胞癌 信号转导 

分 类 号：R730.231[医药卫生—肿瘤]