自身免疫性肝炎的发病机制  

Pathogenesis of Autoimmune Hepatitis

作　　者：俞立飞[1] 黄文豹[1] 许湘飞 金洁[1] 张永乐[2] 梁伟峰[3] YU Li-fei;HUANG Wen-bao;XU Xiang-fei;JIN Jie;ZHANG Yong-le;LIANG Wei-feng(Department of Infectious Diseases,Hangzhou First People s Hospital,Hangzhou 310006,China)

机构地区：[1]杭州市第一人民医院感染科,杭州310006 [2]浙江省立同德医院检验科,杭州310012 [3]浙江大学医学院附属第一医院感染科,杭州310003

出　　处：《中华临床免疫和变态反应杂志》2017年第4期365-369,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：杭州市科技局社会发展项目(20160533B11);浙江省医药卫生科研基金项目(2017KY279)

摘　　要：随着2015年中国自身免疫性肝炎专家共识发布,自身免疫性肝炎越来越受到临床医师的关注。但其确切的病因及发病机制仍不完全明确,目前认为与基因遗传因素和免疫异常相关。本文就基因遗传因素、调节免疫和效应免疫机制在自身免疫性肝炎发病机制中的研究进展作简要综述。Since the release of Chinese expert consensus on autoimmune hepatitis(AIH)in 2015,more and more attention has been paid by physicians to AIH.But the exact etiology and pathogenesis of AIH is still unclear.It is thought to be associated with various genetic and immunological abnormalities.This review summaries the research advance about genetics,regulatory,and effect or immune mechanisms of AIH pathogenesis.

关 键 词：自身免疫性肝炎 基因 免疫 

分 类 号：R575.1[医药卫生—消化系统]