人类免疫缺陷病毒动物模型在相关神经病变的研究应用  

Human immunodeficiency virus animal models and related neuropathy study

作　　者：易智华[1,2] 周聪发 何雪莹[1] 梁尚栋[2] YI Zhi-hua;ZHOU Cong-Fa;HE Xue-ying;LIANG Shang-dong(Nursing College,Nanchang University,Nanchang 330006,China;Dept of Physiology,Basic Medical College,Nanchang University,Nanchang 330006,China;Dept of Anatomy,Basic Medical College,Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学护理学院,江西南昌330006 [2]南昌大学基础医学院生理学教研室,江西南昌330006 [3]南昌大学基础医学院解剖学教研室,江西南昌330006

出　　处：《中国药理学通报》2018年第4期445-449,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 31560276;81570735);江西省科技支撑计划-社会发展支撑计划重点项目(No20151BBG70250);江西省自然科学基金资助项目(No20142BAB205028);江西省教育厅基金资助项目(No GJJ14319)

摘　　要：人免疫缺陷病毒(human immunodeficiency virus,HIV)感染引起全身免疫系统严重损害。HIV感染后病毒产物本身及高效抗逆转录病毒治疗均可引起相关神经病变,包括神经认知功能障碍综合征(HIV associated neurocognitive disorders,HAND)、外周神经病变等并发症。HIV动物模型可对其相关神经病变的发病机制研究提供帮助,该文主要介绍HIV-1动物模型在相关神经病变病理机制的研究应用。Human immunodeficiency virus(HIV)infection may result in serious impairment of the immune system in HIV-positive patients.Both HIV productions and highly active antiretroviral therapy(HAART)drugs can cause neuropathy,including the HIV associated neurocognitive disorders(HAND)and the peripheral neuropathy.Several animal models have been developed in an attempt to study the mechanisms of HIV relative neuropathies.This review focuses on researching HIV-1 associated neuropathies by application of HIV-1 animal models.

关 键 词：人免疫缺陷病毒 人免疫缺陷病毒动物模型 神经认知功能障碍综合征 外周神经病变 神经病理痛 神经炎症 

分 类 号：R-332[医药卫生] R363-332