熊去氧胆酸联合奥美拉唑及莫沙必利治疗胆汁反流性胃炎53例疗效观察  

Ursodeoxycholic acid combined with omeprazole and mosapride in the treatment of bile reflux gastritis in 53 cases

作　　者：班洁虹[1] 杨蔚峰[1] 饶官华[1] 邹尤宝[1] BAN Jiehong;YANG Weifeng;RAO Guanhua;ZOU Youbao(Department of Gstroenterology,The First People’s Hospital of Qinzhou,Qinzhou 535000,China)

机构地区：[1]广西钦州市第一人民医院消化一科,钦州535000

出　　处：《右江医学》2018年第1期60-63,共4页Chinese Youjiang Medical Journal

摘　　要：目的观察熊去氧胆酸联合奥美拉唑及莫沙必利治疗胆汁反流性胃炎的临床效果。方法随机纳入2013年5月至2016年7月治疗的106例胆汁反流性胃炎患者,分为对照组和观察组,每组53例,对照组予口服奥美拉唑、莫沙必利治疗4周,观察组在对照组的基础上加用熊去氧胆酸治疗4周。对比并分析两组的临床疗效及不良反应。结果治疗4周后,临床表现改善情况,观察组有效率为96.23%,对照组有效率为81.13%;胃镜征象改善情况,观察组有效率为92.45%,对照组为79.25%;胃黏膜组织活检病理改善情况,观察组有效率为83.02%,对照组为64.15%;两组间临床表现、胃镜征象及胃黏膜组织活检病理改善情况比较差异均有统计学意义(P<0.05);治疗过程两组均未出现明显的不良反应。结论熊去氧胆酸联合奥美拉唑、莫沙必利治疗胆汁反流性胃炎,能提高治疗效果,且不会增加不良反应,值得应用和推广。Objective To observe the clinical effect of ursodeoxycholic acid combined with omeprazole and mosapride in the treatment of bile reflux gastritis.Methods 106 cases of bile reflux gastritis treated from May,2013 to July,2016 were enrolled in the study and randomly divided into control group and observation group,with 53 cases in each group.The control group were treated with oral omeprazole and mosapride for 4 weeks,and based on which the observation group were treated with ursodeoxycholic acid for 4 weeks.Then,the clinical effects and adverse reactions of the observation group and the control group were compared and analyzed.Results After 4 weeks of treatment,the effective rate of clinical manifestation improvement in the observation group was 96.23%,and that of the control group was 81.13%.The effective rate of improvement of gastroscopy signs in the observation group was 92.45%,and that of the control group was 79.25%.In addition,the effective rate of pathological improvement of biopsy of gastric mucosa tissue in the observation group was 83.02%,and that of the control group was 64.15%.Difference of improvements of clinical manifestations,gastroscopy signs and pathological improvement of biopsy of gastric mucosa tissue was statistically significant(P<0.05).No obvious adverse reactions were found between the two groups during treatment.Conclusion Ursodeoxycholic acid combined with omeprazole and mosapride in the treatment of bile reflux gastritis,can enhance therapeutic effect,and it does not increase the incidence of adverse reactions,which is worthy of application and promotion.

关 键 词：熊去氧胆酸 奥美拉唑 莫沙必利 胆汁反流性胃炎 

分 类 号：R573.34[医药卫生—消化系统]