色素上皮衍生因子的研究进展  

Research progress of pigment epithelium-derived factor

作　　者：何婷 黄跃生[2] 白晓东[1] HE Ting;HUANG Yue-sheng;BAI Xiao-dong(Department of Burn and Plastic Surgery,the General Hospital of Armed Police Forces,Beijing 100039,China;Institute of Burn Research,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)

机构地区：[1]中国人民武装警察部队总医院烧伤整形科,北京医学博士100039 [2]第三军医大学西南医院烧伤研究所,重庆400038

出　　处：《医学研究生学报》2018年第4期419-424,共6页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81401595)

摘　　要：色素上皮衍生因子(PEDF)是具有多种生物学活性的内源性糖蛋白,包括抑制新生血管生成、营养和保护神经元等。最近的研究表明PEDF能够通过抑制血管内皮生长因子(VEGF)的活性来抑制眼部血管的增生和肿瘤血管的生成,同时PEDF还能通过多种信号通路抑制神经退行性病变的发生。文章就PEDF的多种生物学活性以及发挥作用的相关信号通路做一综述,另外结合PEDF的受体深入探讨了其发挥生物学活性的可能机制。Pigment epithelium-derived factor(PEDF)is an endogenously produced protein widely expressed throughout the human body,which exhibits multiple and varied biological actions.Over the past few years,PEDF has been described as a multifaceted protein with anti-angiogenic,neurotrophic,neuroprotective,and anti-permeability.PEDF effectively inhibits vascular endothelial growth factor(VEGF)-driven angiogenesis and vascular permeability by regulating the intracellular proteolysis of VEGF receptors in recent reports.Moreover,PEDF can inhibit the occurrence of neural degenerative diseases through a variety of signaling pathways.The aim of the present review is to discuss the varied biological actions of PEDF and to identify the possible molecular mechanism underlying its effects.

关 键 词：色素上皮衍生因子 血管内皮生长因子 脂肪甘油三酯酯酶 层粘连蛋白受体 

分 类 号：R36[医药卫生—病理学]