慢性皮肤溃疡癌变与癌基因Ras,C-myc异常表达的关系  

Relationship between pathogenesis of chronic skin ulcer and overexpression of Ras and C-myc

作　　者：沈锐[1] 张金明 张凤刚[3] 陈平[1] 杜学亮[1] 黎咏璇[1] 刘必来[1] 邓林[1] 宋红梅 徐路生[4] Shen Rui;Zhang Jingming;Zhang Fenggang;Chen Ping;Du Xueliang;Li Yongxuan;Liu Bilai;Deng lin;Song Hongmei;Xu Lusheng(Department of Plastic and Cosmetic Surgery,First People’s Hospital of Foshan,Foshan 528000,China;Department of Plastic Surgery,Second Affiliated Hospital of Sun Yat-sen University,Guangzhou 450052,China;Department of Burn and plastic Surgery,First People’s Hospital of Foshan,Foshan 528000,China;Department of Hand and Foot Plastic Surgery,First People’s Hospital of Foshan,Foshan 528000,China)

机构地区：[1]广东省佛山市第一人民医院整形美容科,佛山528000 [2]广东省佛山市第一人民医院烧伤整形外科,佛山528000 [3]广东省佛山市第一人民医院手足整形外科,佛山528000 [4]中山大学附属第二医院整形外科,广州450120

出　　处：《中华临床医师杂志（电子版）》2017年第18期2237-2240,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：广东省医学科研基金资助项目(A2012637)

摘　　要：目的探讨Ras,C-myc癌基因异常表达与慢性皮肤溃疡癌变的关系。方法选取10例Marjolin溃疡鳞状细胞癌组织标本。选取10例慢性皮肤溃疡伴假上皮瘤样增生组织标本,选取10例原发性皮肤鳞状细胞癌组织标本,选取5例正常皮肤组织标本。对标本中Ras,C-myc癌基因表达进行免疫组化分析。结果 Marjolin溃疡中鳞状细胞癌组织中,散在癌细胞Ras,C-myc阳性表达,为核染色,而正常组织以及原发性皮肤鳞状细胞癌组织两癌基因均阴性表达,另外,癌基因Ras,C-myc在慢性皮肤溃疡伴假上皮瘤样组织中不典型增生的上皮脚部位,也呈阴性表达。结论 Ras,C-myc的表达异常与慢性皮肤溃疡癌变成鳞状细胞癌有关。Objective To explore the relationship between the abnormal overexpression of Ras and C-myc in chronic ulcers of the skin and the pathogenesis of squamous cell carcinoma(SCC)in Marjolin′s ulcer.Methods Ten tissue specimens of SCC in Marjolin′s ulcer,ten tissue specimens of chronic skin ulcer accompanied with pseudoepitheliomatous hyperplasia,ten tissue specimens of primary SCC,and five tissue specimens of normal skin were collected.The expression of Ras and C-myc in these specimens was detected by immunohistochemistry.Results Both Ras and C-myc were overexpressed in the tissues of SCC in Marjolin′s ulcer.The nuclear staining of Ras and C-myc was positive in some carcinoma cells.However,they were negatively expressed in normal skin tissue and primary SCC cells.They were also not expressed in the epithelial cells with atypical hyperplasia in chronic skin ulcer accompanied with pseudoepitheliomatous hyperplasia.Conclusion The abnormal expression of Ras and C-myc is closely related to the carcinogenesis in chronic ulcer.

关 键 词：Marjolin′s溃疡 鳞状细胞癌 皮肤慢性溃疡 RAS C-MYC 

分 类 号：R632.1[医药卫生—外科学]