VMAT和IMRT技术在鼻咽癌放疗海马保护中可行性研究  

Radiate dosimetry of volumetric modulated therapy on hippocampus in nasopharyngeal carcinoma

作　　者：熊超[1] 叶威[1] 王璐[1] 龚敏勇 XIONG Chao;YE Wei;WANG Lu;GONG Minyong(Cancer Center,Jiujiang First People's Hospital,Jiujiang inJiangxi Province,Jiujiang 333200,China)

机构地区：[1]江西省九江市第一人民医院肿瘤中心,江西九江333200

出　　处：《中国现代医生》2018年第8期79-81,共3页China Modern Doctor

基　　金：江西省九江市科技计划项目(20160102)

摘　　要：目的研究静态调强技术和容积旋转调强治疗技术在治疗鼻咽癌时对海马区的物理剂量学的差异性。方法对2016年5~11月入院的10例鼻咽癌患者采用:(1)容积旋转调强治疗技术V-MAT-HF(对海马区有剂量限制);(2)容积旋转调强治疗技术V-MAT(对海马区不作剂量限制);(3)9野静态调强计划9B-IMRT-HF(对海马区有剂量限制);(4)9野静态调强计划9B-IMRT(对海马区不作剂量限制),记录各患者靶区适形性CI、剂量均匀性HI脑海马区HF的放射剂量,统计剂量学差异。结果鼻咽癌患者靶区容积旋转调强技术(保护脑海马区)对脑海马区的剂量低于其他三种治疗技术,其差异有统计学意义(P<0.05);行保护性照射的容积调强技术对脑海马区HF受照剂量远远低于其他三种治疗技术,差异有统计学意义(P<0.05)。结论 10例鼻咽癌患者靶区容积旋转调强技术(保护脑海马区)对脑海马区的剂量明显低于其他三种治疗技术,VMAT保护海马区技术可以认为是鼻咽癌患者放射治疗的首选治疗技术。Objective To study the differences of physical dosimetry and biological indicators of hippocampus in the treatment of nasopharyngeal carcinoma by different volumetric modulated arc therapies(V-MAT).Methods①V-MAT-HF(dose-limiting for hippocampus),②V-MAT(no dose-limiting for hippocampus),③9-field intensity modulated radiation therapy-HF(9B-IMRT-HF)(dose-limiting for hippocampus)and④9B-IMRT(no dose limitation for hippocampus)were used in 10 cases of nasopharyngeal carcinoma admitted from May 2016 to November 2016 in our hospital.Conformal index(CI),Homogeneity index(HI)and radiation dose of HF in brainstem,spinal cord and hippocampus were recorded.Results The doses of V-MAT-HF(dose-limiting for hippocampus)to the hippocampus in patients with nasopharyngeal carcinoma were significantly lower than those of the other three therapeutic techniques(P<0.05);HF dose to hippocampus of V-MAT with protective radiation was much lower than the other three techniques(P<0.05).Conclusion The dose of V-MAT(protecting the hippocampus)of 10 patients with nasopharyngeal carcinoma is significantly lower than that of the other three therapeutic techniques.V-MAT which protects hippocampus can be considered as the preferred treatment of radiation therapy for patients with nasopharyngeal carcinoma.

关 键 词：鼻咽癌 常规9野静态调强治疗 容积旋转调强治疗 脑海马区放射剂量 

分 类 号：R730.5[医药卫生—肿瘤]