幽门螺杆菌感染与胃癌组织中Ki67及EGFR表达的关系  

Relationship between helicobacter pylori infection and expression of Ki67 and EGFR in gastric carcinoma

作　　者：吴峰阶[1] 朱君[1] 赵大华[2] 胡宝光[1] 孙长华[3] WU Feng-jie;ZHU Jun;ZHAO Da-hua;HU Bao-guang;SUN Chang-hua(Department of Gastrointestinal surgery,Binzhou Medical University Hospital,Binzhou,Shandong,256603;Department of Pathology,Binzhou Medical University Hospital,Binzhou,Shandong,256603;Department of Clinical Laboratory,Binzhou Medical University Hospital,Binzhou,Shandong,256603)

机构地区：[1]滨州医学院附属医院胃肠外科,山东滨州256603 [2]滨州医学院附属医院病理科,山东滨州256603 [3]滨州医学院附属医院检验科,山东滨州256603

出　　处：《临床普外科电子杂志》2017年第3期14-19,共6页Journal of General Surgery for Clinicians(Electronic Version)

基　　金：滨州市科技发展计划项目(2014ZC0132)

摘　　要：目的探讨幽门螺杆菌(helicobacter pylori,Hp)感染与胃癌组织中Ki67与表皮生长因子受体(epidermal growth factor receptor,EGFR)表达的关系。方法收集76例胃癌患者的手术标本及临床资料,采用快速尿素酶法检测Hp感染,采用免疫组化法检查胃癌组织中Ki67与EGFR表达,利用χ2检验、Fisher确切概率法比较及spearman相关分析Hp感染与Ki67及EGFR表达的相关性。结果 76例胃癌患者中Hp阳性组41例,Hp感染阳性率为53.94%;其中Hp阳性组患者胃癌组织中EGFR及Ki67的表达阳性率均显著高于Hp阴性组,差异具有统计学意义(P<0.05),相关性分析表明,EGFR表达(r=-0.401,P=0.001)及Ki67表达(r=-0.370,P=0.003)均与Hp感染呈现明显的负相关。结论 Hp感染阳性胃癌患者肿瘤组织中Ki67和EGFR的表达高于Hp感染阴性的胃癌患者,表明Hp可能通过促进细胞增殖和肿瘤组织血管生成影响胃癌的发生、发展。Objective To explore the correlation between Hp(helicobacter pylori)infection and expression of Ki67,EGFR in patients with gastric cancer.Methods Seventy-six patients with gastric cancer were included in this study,Rapid urease test was used for detection of Hp,immunohistochemistry was used to test expression of Ki67 and EGFR,Chi-Square test,Fisher’s exact test and Spearman correlation was using to investigate the correlationship between Hp infection and expression of Ki67 and EGFR in gastric tumor tissues.Results Forty-one cases of 76 patients with gastric cancer was Hp positive,with a positive rate of 53.94%.Expression of Ki67 and EGFR was significantly higher in Hp positive group than that in Hp negative group(P<0.05),and an obviously negative correlation was found between Hp infection and expression of Ki67(r=-0.370,P=0.003)and EGFR(r=-0.401,P=0.001).Conclusion Expression of Ki67 and EGFR was significantly higher in gastric cancer patients with Hp infection than the patients without Hp infection,which indicated that Hp could promote development of gastric cancer via promotion of cell proliferation and tumor angiogenesis.

关 键 词：胃癌 幽门螺杆菌 KI67 表皮生长因子受体 

分 类 号：R739.42[医药卫生—肿瘤]