帕金森病患者视空间障碍及其相关临床因素的分析  

Analysis of visuospatial impairment in patients with Parkinson's disease and its related clinical factors

作　　者：彭烈标[1] 王海侨[1] 谭峰[1] 王学文[1] 霍绮雯[1] 吴相思 Peng Liebiao;Wang Haiqiao;Tan Feng;Wang Xuewen;Huo Qiwen(Department of Neurology,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China)

机构地区：[1]佛山市中医院神经内科,528000 [2]不详

出　　处：《国际医药卫生导报》2018年第7期977-980,共4页International Medicine and Health Guidance News

基　　金：广东省佛山市卫生局2015年基金资助项目（2015147）

摘　　要：目的 探讨帕金森病(PD)患者视空间障碍及其相关临床因素。方法 用复制立方体评估患者的视空间能力，并选用Hoehn-Yahr分级、UPDRS-Ⅰ、UPDRS-Ⅱ、UPDRS-Ⅲ、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HRSD)、简易精神状态量表（MMSE）等量表评估患者的运动症状、神经精神症状、认知及日常生活活动。结果 在80例PD患者中有44例(55.0%)出现视空间损害。视空间能力与相关因素的Spearman相关分析表明，视空间障碍与H-Y分级、病程、UPDRS-Ⅱ、UPDRS-Ⅲ、是否合并痴呆等有关(P＜0.05)。结论 PD患者视空间障碍的发生可能与UPDRS-Ⅲ及病程有关。我们可以通过综合治疗来改善患者的视空间能力。Objective To study visuospatial impairment in patients with Parkinson's disease(PD)and its related clinical factors.Methods Visuospatial impairment in patients with PD was identified by a cube-copying task.Meanwhile,motor symptoms,neuropsychiatric symptoms,and activities of daily life(ADL)were measured by Hoehn-Yahr scale,Unified Parkinson’s Disease Rating Score-Ⅰ(UPDRS-Ⅰ),UPDRS-Ⅱ,UPDRS-Ⅲ,Hamilton Rating Scale of Depression(HRSD),Mini-Mental State Examination(MMSE).Results Visuospatial impairment was identified in 44 cases of the 80 cases(55.0%).Spearman correlation analysis found that visuospatial impairment was related to Hoehn-Yahr scale,course of disease,UPDRS-Ⅱ,UPDRS-Ⅲ,and dementia(P<0.05).Conclusion UPDRS-Ⅲand course of disease are related to visuospatial impairment in patients with Parkinson's disease.The visuospatial ability of the patients with PD may be improved by comprehensive treatment.

关 键 词：帕金森病 视空间障碍 视觉诱发电位 认知功能 

分 类 号：R742.5[医药卫生—神经病学与精神病学]