AMA-M2、SP100和GP210在诊断原发性胆汁性肝硬化中的应用评估  

Evaluation of AMA-M2,SP100 and GP210 in the diagnosis of primary biliary cirrhosis

作　　者：俞辉[1] 宋金龙[1] 陈定强[1] 林勇平[1,2] 刘忠民[1] 刘利东[1] YU Hui;SONG Jinlong;CHEN Dingqiang;LIN Yongping;LIU Zhongmin;LIU Lidong(Department of Laboratory Medicine,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China;Translational Medicine Research Laboratory,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]广州医科大学附属第一医院检验科,广州510120 [2]广州医科大学附属第一医院转化医学研究实验室,广州510120

出　　处：《广州医药》2018年第2期38-41,49,共5页Guangzhou Medical Journal

基　　金：广州医科大学附属第一医院青年基金项目(201535-gyfyy)

摘　　要：目的评估AMA-M2、SP100和GP210三种自身抗体在诊断原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)中的应用价值。方法收集我院近3年就诊患者的AMA-M2、SP100、GP210、ALP和GGT检测数据,其中PBC患者50例,非PBC肝胆疾病或自身免疫病患者226例,正常对照290例。分析这些检测指标对PBC诊断的敏感度和特异度。结果 AMA-M2、SP100和GP210诊断原发性胆汁性肝硬化的敏感度分别为96.00%、36.00%、8.00%,特异度分别为98.26%、97.87%、99.03%。PBC组病人的ALP和GGT检测结果高于非PBC病人组。结论 AMA-M2、SP100和GP210对PBC的临床诊断特异度较高;AMA-M2的敏感度高,但SP100和GP210敏感度低。Objective To evaluate the diagnostic accuracy of AMA-M2,SP100 and GP210 for the primary biliary cirrhosis(PBC).Methods A total of 50 patients with PBC and 226 patients with other liver diseases or autoimmune diseases were enrolled in this study and 290 healthy individuals were included as normal controls.The data of AMA-M2,SP100,GP210,ALP and GGT were collected and analyzed for sensitivity and specificity in the diagnosis of PBC.Results The sensitivity and specificity of AMA-M2,SP100 and GP210 in the diagnosis of PBC were 96.00%,36.00%,8.00%and 98.26%,97.87%,99.03%,respectively.Compared to PBC group,the concentrations of ALP and GGT in non-PBC patients and controls were low.Conclusion AMA-M2 is quite accurate with high specificity and sensitivity in the diagnosis of PBC.However,SP100 and GP210 have high sensitivity but low sensitivity.

关 键 词：原发性胆汁性肝硬化 AMA-M2 SP100 GP210 

分 类 号：R446.6[医药卫生—诊断学] R575.22[医药卫生—临床医学]