兔心房组织内向整流钾2.1通道基因表达的增龄性变化  

Age-related changes in gene expression of inward rectifier potassium 2.1 channel of rabbit atrial tissues

作　　者：酉鹏华 陈海潮[1] 寿锡凌[1] 程功[1] 何晓敏 YOU Peng-hua;CHEN Hai-chao;SHOU Xi-ling;CHENG Cheng;HE Xiao-ming(Department of Cardiology,Shaanxi Provincial People′s Hospital,Xi′an 710068,China;Department of Internal Medicine,the Hospital of Xi′an University of Technology,Xi′an 710068,China)

机构地区：[1]陕西省人民医院心血管内科,西安市710068 [2]西安理工大学校医院内科,陕西省西安市710068

出　　处：《广西医学》2018年第5期546-548,共3页Guangxi Medical Journal

基　　金：中国医师协会房颤专项基金(2013-1-21)

摘　　要：目的观察家兔心房内向整流钾2.1(Kir2.1)通道mRNA表达的增龄性变化。方法选择家兔24只,分为幼年组(14~21 d)、成年组(8~10个月)、老年组(30~35个月),每组8只。采用实时荧光定量PCR检测各组家兔心房组织的钾内向整流通道超家族J成员2(KCNJ2)mRNA表达情况。结果幼年组、成年组及老年组的KCNJ2 mRNA相对表达量依次升高(均P<0.05)。结论 Kir2.1通道在转录水平随着年龄增加而发生变化,这可能是老年人房颤高发生率的因素之一。Objective To observe the age-related changes in mRNA expression of inward rectifier potassium 2.1(Kir2.1)channel of rabbit atrial tissues.Methods Twenty-four rabbits were divided into infancy group(aged 14-21 days),mature group(aged 8-10 months)and senile group(aged 30-35 months),with 8 rabbits in each group.The mRNA expression of inward rectifier potassium voltage-gated channel subfamily J,member 2(KCNJ 2)were analyzed in the rabbit atrial tissues of each group by quantitative real-time PCR.Results The related expressions of KCNJ 2 mRNA increased in the order of the infancy group,the mature group and the senile group(all P<0.05).Conclusion The transcription level of Kir2.1 channel changes with the increase of age,which is probably one of the factors influencing the high incidence rate of atrial fibrillation in the elderly.

关 键 词：心房颤动 增龄性 内向整流钾2.1通道 基因表达 兔 

分 类 号：R363[医药卫生—病理学]