胃癌骨转移患者临床病理特征及预后影响因素分析  

Clinical features and prognosis of gastric cancer with bone metastasis

作　　者：范志松[1] 邢栋[2] 左静[1] 王龙[1] 齐永霞[3] 李瑞晓 吕冬婕[5] Zhi-song Fan;Dong Xing;Jing Zuo;Long Wang;Yong-xia Qi;Rui-xiao Li;Dong-jie Lü(Department of Oncology,the Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei 050011,China;Department of Orthopedics,Hebei General Hospital,Shijiazhuang,Hebei 050051,China;Department of Oncology,Dingzhou City People’s Hospital,Dingzhou,Hebei 073000,China;Department of Thoracic Oncology,Xingtai Longyao County Hospital,Xingtai,Hebei 055350,China;Department of Radiation Oncology,the Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei 050011,China)

机构地区：[1]河北医科大学第四医院肿瘤内科,河北石家庄050011 [2]河北省人民医院骨一科,河北石家庄050051 [3]河北省定州市人民医院肿瘤科,河北定州073000 [4]河北省邢台市隆尧县医院胸外肿瘤科,河北邢台055350 [5]河北医科大学第四医院放五科,河北石家庄050011

出　　处：《中国现代医学杂志》2018年第11期79-83,共5页China Journal of Modern Medicine

摘　　要：目的对胃癌骨转移患者临床病理特征及预后进行回顾性分析。方法收集2005~2015年收治的胃癌骨转移患者139例,分析患者临床病理特征和治疗对患者生存时间的影响。结果胃癌患者常见的骨转移部位依次为脊柱、骨盆及肋骨。胃癌骨转移患者中位生存时间15.1个月,确诊骨转移后患者中位生存时间为5.7个月。TNM分期、同时或异时性骨转移、是否化疗及是否双膦酸盐治疗是影响胃癌骨转移患者总生存期的独立预后因素(P<0.05)。而骨转移后是否接受化疗是影响患者骨转移后生存期的独立预后因素(P<0.05)。结论骨转移多发生于胃癌病程晚期,患者一旦发生骨转移则提示预后差,化疗可延长患者骨转移后的生存时间。临床医生应注意筛查并采取积极的治疗措施延长患者生存期。Objective To evaluate the clinicopathological characteristics and outcomes of gastric cancer patients with bone metastasis.Methods The subjects were 139 gastric cancer patients who were diagnosed with bone metastasis between 2005 and 2015.The influences of pathological characteristics and clinical treatment on the survival time of the patients were analyzed.Results The common sites of bone metastasis were spine,pelvis and ribs.The median survival time of the gastric cancer patients with bone metastasis was 15.1 months,but the median survival time after diagnosis of bone metastasis was only 5.7 months.Tumor stage,simultaneous bone metastasis or not,chemotherapy and bisphosphonate therapy were the independent prognostic factors for overall survival in the gastric patients with bone metastasis(P<0.05).Whether received chemotherapy or not after bone metastasis was an independent prognostic factor for patients’survival(P<0.05).Conclusions Bone metastasis usually occurs inadvanced stage of gastric cancer,and indicates poor prognosis.After bone metastasis,accepting chemotherapy can prolong the survival time of the patients.Clinicians should pay more attention and provide active therapy to the gastric cancer patients with bone metastasis.

关 键 词：胃癌 骨转移 临床特征 化疗 预后 

分 类 号：R735.2[医药卫生—肿瘤]