ADRB2基因多态性与aSAH迟发性脑血管痉挛的关联性研究  

Association between Polymorphism of Beta-2 Adrenergic Receptor and Delayed Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage

作　　者：董发达 马晓虎 田冰锋[2] DONG Fa-da;MA Xiao-hu;TIAN Bing-feng(Department of Neurosurgery,First people’s Hospital of Xianyang,Shanxi,712000,China;Department of Neurosurgery,Hazhong central hospital,Shanxi 723000,China)

机构地区：[1]咸阳市第一人民医院神经外科,陕西咸阳712000 [2]汉中市中心医院神经外科,陕西汉中723000

出　　处：《神经损伤与功能重建》2018年第1期6-8,12,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨中国北方汉族人群中,动脉瘤性蛛网膜下腔出血(aSAH)后迟发性脑血管痉挛(DCVS)与β2肾上腺素能受体(ADRB2)基因多态性的关系。方法:aSAH患者206例纳入研究,按照是否合并DCVS分为DCVS组128例和无DCVS组78例,采用聚合酶链反应-限制性片段长度多态性法检测ADRB2基因A46G位点和C79G位点多态性。结果:单因素分析结果显示ADRB2基因A46G位点等位基因模型(A vs.G)和显性基因模型(A/A vs.A/G+G/G)均与DCVS发生相关;多因素Logistics回归分析结果显示ADRB2基因+46位点等位基因G和基因型(A/G+G/G)与aSAH患者发生DCVS的危险因素(OR=1.414,95%CI:1.142~4.817,P=0.039;OR=1.337,95%CI:1.076~3.191,P=0.045);C79G位点各基因模型与DCVS相关性均无统计学意义。结论:对于中国北方汉族aSAH患者,ADRB2基因A46G位点多态性与DCVS发生相关。Objective:To investigate the genetic association between Beta-2 Adrenergic Receptor(ADRB2)gene polymorphism and delayed cerebral vasospasm(DCVS)in patients with aneurysmal subarachnoid hemorrhage(aSAH)in the Han descent population in No$h of China.Metliods:Two hundred and six aSAH patients were recruited.According to whether DCVS occurred,cases were divided into the DCVS group(n=128)and the non-DCVS group(n=78).Polymerase chaiii reaction-restriction fragment lengh polymoynisln combined with DNA diect sequencing technique were used to determine the polymoyhisln of the ADRB2 gene.Results:Univariate analysis showed independent association between allele model vs.G)and the domuiant model(A/A v.A/G+G/G)of ADRB2 gene A46G polymoyhism and DCVS.Multivariate Logistic regression showed that ADRB2 gene+46 position allele G and genotyye(AG+G/G)were rsk factors of DCVS for aSAH patients(OR=1.414,95%CI 1.142?4.817,PX.039;OR=1.337,95%CI 1.076~3.191,P-0.045).However,there was no significant difference in the frequencies of genotype and allele of C79G polymorphism between the DCVS group and the non-DCVS group Conclusion:For aSAH patients in the Han descent N〇rh of China,A46G polymorpMsm ofA.DRB2 gene may closely related to DCVS.

关 键 词：Β2肾上腺素能受体 动脉瘤性蛛网膜下腔出血 迟发性脑血管痉挛 基因多态性 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]