动脉热灌注化疗联合超选择栓塞治疗不可切除结直肠癌肝转移的临床研究  

Clinical observation of transarterial hyperthermic perfusion chemotherapy combined with superselective arterial embolization for the treatment of unresectable colorectal cancer liver metastasis

作　　者：郭亚潘 孙鹏程 陆珏清 朱碧云 孙敬[1] 张鑫[1] Guo Yapan;Sun Pengcheng;Lu Jueqing;Zhu Biyun;Sun Jing;Zhang Xin(Department of Radiology,,Suzhou Xiangcheng People's Hospital,Suzhou 215131,China;Department of Operation Room,Suzhou Xiangcheng People's Hospital,Suzhou 215131,China)

机构地区：[1]苏州市相城人民医院放射科 [2]苏州市相城人民医院手术室

出　　处：《中华介入放射学电子杂志》2018年第1期32-36,共5页Chinese Journal of Interventional Radiology：electronic edition

摘　　要：目的:研究动脉热灌注化疗联合超选择栓塞治疗不可切除结直肠癌肝转移的效果。方法:选取2014年1月—2016年7月我科诊治的39例结直肠癌肝转移患者,分为2组,研究组(22例)在肠系膜上动脉、肝固有动脉以51℃灌注化疗1 h,然后超选择至肝脏病灶的供血动脉,进行化疗栓塞。对照组(17例)接受传统的肝动脉化疗栓塞(TACE)治疗。比较2组的客观有效率、临床获益率及1年生存率。同时记录并比较两组的不良反应。结果:两组的客观有效率无统计学差异(27.3%vs.23.5%,P>0.05),临床获益率也无统计学差异(81.8%vs.76.5%,P>0.05)。但研究组的1年生存率显著高于对照组(63.2% vs.46.7%,P<0.05)。两组都未出现血管痉挛、闭塞等特殊并发症。结论:动脉热灌注化疗联合超选择栓塞治疗不可切除结直肠癌肝转移的远期效果优于传统TACE。Objective:To evaluate the effect of transarterial hype rthemic perfusion chemotherapy combined with arterial su perselective embolization for the treatment of unresecta ble colorectal cancer liver metastasis.Methods:A retro spective analysis of the clinical data of 39 cases with co lorectal cancer liver metastasis was conducted.The trea tment group included 22 cases.Transarterial hyperthemic perfusion(51℃,1 h)was performed in superior mesenteric artery and hepatic artery respectively.And then super se lective artery embolization was performed in the feeding artery of hepatic lesions.Control group included 17 case s who received traditional transcatheter arterial chemoe mbolization(TACE).The short-term effect was evaluated b y objective response rate and clinical benefit rate.One year survival rate was used to evaluate the long-term effe ct.At the same time,adverse reactions of two groups were recorded.Results:There was no significant difference between the basic clinical characteristics of patients i n two groups.The objective effective rate showed no sign ificant difference(27.3%vs.23.5%,P>0.05)between the two groups and the clinical benefit rate also showed no si gnificant difference(81.8%vs.76.5%,P>0.05).However,the one year survival rate of study group was significant ly higher than the control group(63.2%vs.46.7%,P<0.05).There were no artery vasospasm,occlusion,or any othe r serious adverse reactions in two groups.Conclusions: The long-term effect of transarterial hyperthemic perfus ion chemotherapy combined with arterial superselective e mbolization on unresectable colorectal cancer liver meta stasis is superior to that of conventional TACE.

关 键 词：动脉热灌注化疗 肝动脉化疗栓塞 结直肠癌肝转移 

分 类 号：R735.3[医药卫生—肿瘤]