强迫症的认知行为治疗及相关神经影像研究进展  

Research Progress of Cognitive Behavior Therapy and Related Neuroimaging for Obsessive-Compulsive Disorder

作　　者：赵科[1] 杨峘[2] 曹玉萍[2] 李飞[3] 张宇[2] 张亚林[2] Zhao Ke;Yang Huan;Cao Yuping;Li Fei;Zhang Yu;Zhang Yalin(Chongqing Mental Health Center,Chongqing,China 401147;Institute of Mental Heslth,The Second Xiangya Hospital of Central South University,Changsha,Hunan,China 410011;Mental Health Center,Xiangya Hospital of Central South University,Hunan,China 4100008)

机构地区：[1]重庆市精神卫生中心,重庆401147 [2]中南大学湘雅二医院精神卫生研究所,湖南长沙410011 [3]中南大学湘雅医院心理卫生中心,湖南长沙410008

出　　处：《中国药业》2018年第3期92-95,共4页China Pharmaceuticals

基　　金：国家自然科学基金青年基金[81601199]

摘　　要：该文综述了强迫症的认知行为治疗及对其相关的神经影像研究。认知行为治疗被认为是强迫症的一线疗法,但其作用机制却不甚清楚。神经影像学研究显示,强迫症涉及眶额叶皮层、前扣带皮层、背外侧前额叶皮层、尾状核及丘脑等脑区。病理模型集中于眶额叶-纹状体-丘脑环路异常。认知行为治疗可能作用于某些脑区或眶额叶-纹状体-丘脑环路上的某些靶点,从而改善强迫症症状。This article reviews the cognitive behavior therapy of obsessive-compulsive disorder(OCD)and its related neuroimaging studies,cognitive behavior therapy is recommended as first line therapy for OCD,but its mechanism is not very clear.Neuroimaging studies have shown that OCD involves the orbitofrontal cortex,anterior cingulate cortex,dorsolateral prefrontal cortex,caudate nucleus and the thalamus.The pathological model focuses on abnormal of orbital frontal cortex-striatum-thalamus circle.Cognitive behavior therapy may improve the symptoms of OCD by acting on some brain regions or some targets of orbital frontal cortex-striatum-thalamus circle.

关 键 词：认知行为治疗 强迫症 神经影像 眶额叶 纹状体 丘脑 进展 

分 类 号：R741[医药卫生—神经病学与精神病学]