神经节苷脂联合盐酸普拉克索对帕金森患者非运动症状及血清Cys C、S-100B、NSE含量的影响  

Effects of ganglioside combined with pramipexole hydrochloride on non-motor symptoms and serum Cys C,S-100B and NSE in patients with Parkinson's disease

作　　者：谭文用 邹晓毅[2] 周沐科[2] 钟强[3] ZOU Xiao-yi;ZHOU Mu-ke;ZHONG Qiang(Department of Neurology,Tongjiang County Hospital of Traditional Chinese Medicine,Tongjiang 636700,China;Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Neurology,Sichuan Traditional Chinese Medicine and Western Medicine Hospital,Chengdu 610041,China)

机构地区：[1]四川省通江县中医院神经内科,四川通江636700 [2]四川大学华西医院神经内科,四川成都610041 [3]四川省中西医结合医院神经内科,四川成都610041

出　　处：《实用医院临床杂志》2018年第2期125-128,共4页Practical Journal of Clinical Medicine

摘　　要：目的探讨神经节苷脂联合盐酸普拉克索对帕金森(Parkinson's disease,PD)患者非运动症状及血清胱抑素C(Cys C)、中枢神经特异蛋白(S-100B)、神经元特异性烯醇化酶(NSE)水平影响。方法 104例PD患者采用随机数字表法分为观察组和对照组各52例,对照组给予多巴丝肼片治疗,观察组在对照组基础上给予盐酸普拉克索+静脉滴注神经节苷脂治疗。比较两组治疗前后情绪障碍、认知障碍、睡眠障碍、自主神经障碍和感觉障碍等非运动症状变化以及血清Cys C、S-100B、NSE含量变化。结果治疗后观察组汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠指数量表(PSQI)和Epworth嗜睡程度评价表(ESS)评分低于对照组,简易智能状态量表(MMSE)、帕金森病睡眠量表(PDSS)评分高于对照组;自主神经障碍和感觉障碍发生率、血清Cys C、S-100B和NSE水平均低于对照组(P<0.05)。结论神经节苷脂联合盐酸普拉克索可显著改善PD患者非运动症状,降低血清Cys C、S-100B、NSE含量。To explore the effects of ganglioside combined with pramipexole hydrochloride on non-motor symptoms and the levels of serum cystatin C(Cys C),central nerve specific protein(S-100B)and neuron specific enolase(NSE)in patients with Parkinson s disease(PD).One hundred and four PD patients were divided into observation or control group according to the random number table method,52 in each group.The control group was given levodopa and benserazide tablet while the observation group was given pramipexole hydrochloride and intravenous drip of ganglioside on the based of the control group.The mood disorders,cognitive impairment,sleep disorders,autonomic disorders and sensory disorders and other non-motor symptoms changes as well as changes of serum Cys C,S-100B and NSE were compared between the two groups before and after treatment.After treatment,the scores of Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),Pittsburgh sleep quality index(PSQI)and Epworth sleepiness scale(ESS)in the observation group were significantly lower than those in the control group while the scores of Mini Mental State Examination(MMSE)and Parkinson s disease sleep scale(PDSS)were higher in the observation group than those in the control group(all P<0.05).The incidence of autonomic nerve disorders and sensory disorders in the observation group were significantly lower than those in the control group.The serum levels of Cys C,S-100B and NSE in the observation group were significantly lower than those in the control group(P<0.05).Ganglioside combined with pramipexole hydrochloride can significantly improve the non-motor symptoms,and reduce the content of serum Cys C,S-100B and NSE in PD patients.

关 键 词：神经节苷脂 盐酸普拉克索 帕金森 非运动症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]