TLR4介导中药干预脑缺血炎症损伤的研究进展  

Review of Chinese herbal medicine's protective mechanisms against cerebral ischemia inflammatory injury via TLR4

作　　者：岳少乾 孙作艳 李霖[1] 张翕婷 朱金墙[1] 张晗[1] YUE Shaoqian;SUN Zuoyan;LI Lin;ZHANG Xiting;ZHU Jinqiang;ZHANG Han(Tianjin University of Traditional Chinese Medicine,TianJin,300193,China)

机构地区：[1]天津中医药大学,天津300193

出　　处：《天津中医药大学学报》2018年第2期173-176,共4页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81273815)

摘　　要：脑缺血后的炎症反应是加重脑缺血损伤的重要病理机制之一。Toll样受体4(TLR4)在炎症反应中发挥重要的作用。近年来研究表明,中药可有效干预炎症反应的诸多环节从而减轻脑缺血损伤。文章就中药以TLR4为靶点干预脑缺血损伤过程中的炎症反应的研究做一综述,旨在为以TLR4为靶点治疗脑缺血炎症损伤的研究提供参考。Inflammation following cerebral ischemia is one of the most important pathomechanisms to aggravate brain injury.Toll-like receptors 4(TLR4)counts more in inflammation.And according to recent studies,traditional Chinese medicine(TCM)can effectively protect cerebral ischemia inflammatory injury.Thus,we merely summarize the advance of TCM in the protection of cerebral ischemia injury viaTLR4 in order to provide basis and reference for the anti-inflammatory therapy of this aspect.

关 键 词：中药 脑缺血损伤 TOLL样受体4 

分 类 号：R743[医药卫生—神经病学与精神病学]