甘露醇不同服用频次对结肠镜检查术肠道准备效果的影响  

Effect of different frequency of mannitol on bowel preparation for colonoscopy

作　　者：赵欣[1] 金世柱[1] 吕志武 张菲菲[1] 张春伟[1] 刘自帅 李国庆[1] ZHAO Xin;JIN Shi-zhu;LV Zhi-wu;ZHANG Fei-fei;ZHANG Chun-wei;LIU Zi-shuai;LI Guo-qing(Department of Gastroenterology and Hepatology,The second affiliated hospital of Harbin Medical University,Harbin City,Hei鄄longjiang Province 150086;Department of Gastroenterology and Hepatology,People’s Hospital of Baoan District,Shenzhen,Shenzhen City,Guangdong Province 518100)

机构地区：[1]哈尔滨医科大学附属第二医院消化内科,150081 [2]深圳市宝安区人民医院消化内科,518100

出　　处：《现代消化及介入诊疗》2018年第1期22-25,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的比较单次服用甘露醇方案与分次服用甘露醇方案对结肠镜检查术肠道准备的有效性和安全性。方法将600例欲行结肠镜检查的研究对象按就诊顺序分为两组:单次服用甘露醇组和分次服用甘露醇组,每组300人。研究对象填写肠道准备表,结肠镜检查结束后由内镜医师进行肠道清洁度评分。结果对579例研究对象的资料进行了分析。分次服用甘露醇组的BBPS评分高于单次服用甘露醇组(P<0.01);分次服用甘露醇组的OBPS评分低于单次服用甘露醇组(P<0.05)。分次服用甘露醇组与单次服用甘露醇组相较,恶心及腹胀发生的情况较少(P<0.05)。两组其他不良反应事件发生率相似。结论分次服用甘露醇方案的肠道准备效果优于单次服用甘露醇方案,副反应发生率低。Aims This study aimed to compare the effectiveness and safety between single mannitol regimen and split-dose mannitol regimen for bowel preparation for colonoscopy.Methods A total 600 study subjects for colonoscopy were divided into two groups according to the order of treatment:single mannitol group and split-dose mannitol group,300 subjects in each group.Colonoscopic physicians did not know the study subjects grouping.After the end of the colonoscopy,the study subjects were asked to complete the bowel preparation schedules.The endoscopic physician performed an intestinal cleanliness scale(Boston Bowel Preparation Scale,BBPS;Ottawa Bowel Preparation Scale,OBPS)and collected colonoscopy report.Results A total of 579 study subjects were included in the analysis.The BBPS score of the split-dose mannitol group was higher than that of the single mannitol group(P<0.01).The OBPS score of the split-dose mannitol group was lower than that of the single mannose group(P<0.05).Nausea and bloating occurred less frequently in split-dose mannitol group(P<0.05).The incidence of other adverse events was similar in both groups.Conclusions The split-dose mannitol regimen is superior to single mannitol regimen in bowel cleaning.The incidence of side effects is low and the study subjects are well tolerated.

关 键 词：甘露醇 肠道准备 结肠镜检查 分次 

分 类 号：R574.62[医药卫生—消化系统]