非小细胞肺癌患者血清IL-17、VEGF水平与临床分期和预后的相关性研究  

Correlation of serum IL-17 and VEGF levels with clinical stage and prognosis in patients with non-small cell lung cancer

作　　者：叶飒[1] 王飞燕[1] 周宏斌[1] 喻飒[1] 林帆 YE Sa;WANG Feiyan;HOU Hongbin(Department of Respiratory Medicine,Zhejiang Provincial People's Hospital(People's Hospital of Hangzhou Medical College),Hangzhou 310014,China)

机构地区：[1]浙江省人民医院(杭州医学院附属人民医院)呼吸内科,杭州310014

出　　处：《浙江医学》2018年第6期573-576,共4页Zhejiang Medical Journal

基　　金：浙江省自然科学基金资助项目(LY17H160063);浙江省医药卫生科技计划项目(2017KY196)

摘　　要：目的研究非小细胞肺癌(NSCLC)患者血清IL-17、血管内皮生长因子(VEGF)水平与临床分期和生存预后的相关性。方法采用酶联免疫吸附实验(ELISA法)检测103例NSCLC患者和50例正常对照者血清IL-17、VEGF水平。分析NSCLC患者血清IL-17和VEGF水平两者之间的关系,分析IL-17、VEGF水平与TNM分期和预后的关系,采用Cox比例风险回归模型进行多因素预后分析。结果 NSCLC患者血清IL-17和VEGF水平较正常对照组显著增高(均P<0.01)。Ⅰ~Ⅱ期与Ⅲ、Ⅳ期患者血清VEGF水平两两比较差异均有统计学意义(均P<0.05);血清IL-17水平Ⅰ~Ⅱ期与Ⅲ、Ⅳ期比较,差异均有统计学意义(均P<0.01),而Ⅲ、Ⅳ期之间比较差异无统计学意义(P>0.05)。NSCLC患者血清IL-17与VEGF水平呈正相关(r2=0.745,P<0.01)。血清IL-17、VEGF水平高的患者中位生存时间较短,差异有统计学意义(均P<0.01)。多因素分析显示,血清IL-17、VEGF水平和TNM分期是独立的预后影响因素(均P<0.05)。结论 NSCLC患者血清IL-17、VEGF水平与NSCLC的TNM分期及生存预后密切相关,两者可作为NSCLC诊断和判断预后的检测指标。Objective To investigate the relationship of serum IL-17 and VEGF with TNM stage and survival in patients with non-small-cell lung cancer(NSCLC).Methods Serum specimens from 103 patients with NSCLC and 50 healthy controls were collected.The concentrations of IL-17 and VEGF were measured using enzyme-linked immunosorbent assay,and the relationship of serum IL-17 and VEGF levels with TNM stage and survival of NSCLC patients was analyzed with COX proportional hazards regression model.Results Serum IL-17 and VEGF levels were higher in the NSCLC patients than those in the control group(P<0.01).There were significant differences in the levels of serum IL-17 and VEGF between patients with stage I-II and stage III(P<0.01),between stage I-II and stage IV(P<0.01).There was no significant difference in IL-17 levels between stage III and stage IV(P>0.05).There was a positive relationship between serum IL-17 and VEGF(r2=0.745,P<0.01).The median survival time of patients with higher serum IL-17 and VEGF levels was shorter(P<0.01).Multivariate analysis showed that serum VEGF and IL-17 levels and TNM stage were independent prognostic factors(P<0.01).Conclusion The levels of serum IL-17 and VEGF are closely related to the TNM stage and survival of patients with NSCLC,indicating that IL-17 and VEGF might be used as indicators for the diagnosis and prognosis of NSCLC patients.

关 键 词：非小细胞肺癌 白介素-17 血管内皮生长因子 TNM分期 预后 

分 类 号：R734.2[医药卫生—肿瘤]