住院精神分裂症并发糖尿病患者与抗精神病药物应用的关系分析  

Analysis of Correlation between the Schizophrenia Complicated by Diabetes and Antipsychotic Drugs of Inpatients

作　　者：张永艳[1] 王秀梅[1] 赵景新[2] 宋长惠 董万森[1] 郝娣 ZHANG Yong-yan;WANG Xiu-mei;ZHAO Jing-xin;SONG Chang-hui;DONG Wan-sen;HAO Di(Seventh Department of Psychiatry,Changping District Integrated Traditional Chinese and Western Medicine Hospital,Beijing,100096 China;Department of Nephrology,Changping District Integrated Traditional Chinese and Western Medicine Hospital,Beijing,100096 China;First Department of Psychiatry,Changping District Integrated Traditional Chinese and Western Medicine Hospital,Beijing,100096 China)

机构地区：[1]北京市昌平区中西医结合医院精神七科,北京100096 [2]北京市昌平区中西医结合医院肾内科,北京100096 [3]北京市昌平区中西医结合医院精神一科,北京100096

出　　处：《系统医学》2017年第22期34-35,40,共3页Systems Medicine

摘　　要：目的探讨住院精神分裂症并发糖尿病患者与抗精神病药物应用的关系。方法选取2014年1月—2017年2月在该院住院治疗的65例精神分裂症患者,根据抗精神病药物使用情况分为阿立哌唑(35例)、喹硫平(19例)和利培酮组(11例),分析抗精神病药物治疗对血糖水平与糖尿病发生率的影响。结果喹硫平组和利培酮组患者服药后FPG值分别达到了(6.22±0.98)、(6.64±1.02)mmol/L,均明显高于服药前(P<0.05);阿立哌唑组服药前后FPG值分别为(5.22±1.50)、(5.43±1.33)mmol/L,差异无统计学意义(P>0.05)。喹硫平组和利培酮组患者末次血糖水平均随着时间的延长不断升高,两组中住院时间在1年以上的患者末次血糖水平与住院时间<1年的患者相比差异有统计学意义(P<0.05);在糖尿病发生率方面,3组患者由高到低依次为:喹硫平组(15.79%)>利培酮组(9.09%)>阿立哌唑组(0.00%),3组血糖增高与糖尿病发生率均差异有统计学意义(P<0.05)。结论喹硫平与利培酮对住院精神分裂症患者的血糖代谢影响最大,而且影响更加长远,需进一步规范抗精神病药物的使用,加强血糖监测。Objective To study the correlation between the schizophrenia complicated by diabetes and antipsychotic drugs of inpatients.Methods 65 cases of patients with schizophrenia treated in our hospital from January 2014 to February 2017 were selected and divided into three groups according to the use of antipsychotic drugs,including the aripiprazole group with 35 cases,quetiapine group with 19 cases and risperidone group with 11 cases,and the effect of antipsychotic drugs on the blood glucose level and incidence rate of diabetes was analyzed.Results After medication,the FPG values in the quetiapine group and in the risperidone group reached(6.22±0.98),(6.64±1.02)mmol/L,which were obviously higher than those before medication(P<0.05),and the FPG values in the aripiprazole group before and after medication were respectively(5.22±1.50),(5.43±1.33)mmol/L,and the differences were not obvious(P>0.05),and the with the time prolonging,the last blood glucose level in the quetiapine group and in the risperidone group also increased,and the difference in the last blood glucose level between patients whose length of stay>1 year and patients whose length of stay<1 was obvious(P<0.05),and the incidence rate of diabetes in the quetiapine group,risperidone group and aripiprazole group(15.79%>9.09%>0.00%),and the difference in the hyperglycemia and incidence rate of diabetes of the three groups was obvious(P<0.05).Conclusion The effect of quetiapine and risperidone on the glucose metabolism of inpatients with schizophrenia is the biggest and long,and we need to further standardize the use of antipsychotic drugs and enhance the monitoring of blood glucose.

关 键 词：精神分裂症 糖尿病 合并症 抗精神病药物 

分 类 号：R749.3[医药卫生—神经病学与精神病学]