术侧肺间断机械通气对肺切除术后患者复张性肺水肿的预防效果分析  

Analysis of Effect of Pulmonary Intermittent Mechanical Ventilation in Preventing the Reexpansion Pulmonary Edema of Patients with Lung Resection

作　　者：何学东[1] 张同钦[1] 王世平[1] 马伟[1] HE Xue-dong;ZHANG Tong-qin;WANG Shi-ping;MA Wei(Department of Chest Surgery,Jianyang People’s Hospital,Jianyang,Sichuan Province,641400 China)

机构地区：[1]简阳市人民医院胸外科,四川简阳641400

出　　处：《系统医学》2017年第24期66-68,共3页Systems Medicine

摘　　要：目的探讨不同通气治疗在肺切除术中对复张性肺水肿的预防作用。方法分别以该院不同时期收治的肺切除术患者作为研究对象,其中2015年1月—2016年1月期间入院的30例肺切除术患者为对照组,采用常规单肺通气;2016年2月—2017年2月收治的35例肺切除术患者为实验组,采用术侧肺间断机械通气,对比两组患者并发症发生与水通道蛋白表达情况。结果实验组患者复张性肺水肿发生率28.6%明显低于对照组的66.7%,差异有统计学意义(χ~2=18.296,P<0.05);低氧血症发生率71.4%与对照组的70.0%相近,差异无统计学意义(χ~2=0.824,P>0.05)。实验组患者的水通道蛋白1(AQP-1)和水通道蛋白5(AQP-5)水平表达分别为(0.58±0.11)、(0.67±0.18)明显优于对照组,差异有统计学意义(t=5.938、6.384,P<0.05)。结论术侧肺间断机械通气能够降低肺切除术后复张性肺水肿的发生率,为临床肺切除术后并发症的预防提供一定的参考。Objective To study the effect of pulmonary intermittent mechanical ventilation in preventing the reexpansion pulmonary edema of patients with lung resection.Methods 30 cases of lung resection patients admitted and treated in our hospital from January 2015 to January 2016 were selected as the control group,and used the routine single lung ventilation,while 35 cases of lung resection patients admitted and treated in our hospital from February 2016 to February 2017 were selected as the experimental group,and used the pulmonary intermittent mechanical ventilation,and the occurrence of complications and expression of aquaporin were compared between the two groups.Results The incidence rate of reexpansion pulmonary edema in the experimental group was obviously lower than that in the control group,(28.6%vs 66.7%),and the difference was statistically significant(χ2=18.296,P<0.05),and the incidence rate of hyoxemia in the two groups was similar(71.4%vs 70.0%),and there was no obvious difference(χ2=0.824,P>0.05),and the expressions of AQP-1 and AQP-5 in the experimental group were respectively(0.58±0.11),(0.67±0.18),which were obviously better than those in the control group,and the differences were statistically significant(t=5.938,6.384,P<0.05).Conclusion The pulmonary intermittent mechanical ventilation can reduce the incidence rate of reexpansion pulmonary edema of patients with lung resection thus providing a certain reference for the clinical prevention of complications after the clinical lung resection.

关 键 词：术侧肺间断机械通气 肺切除术 复张性肺水肿 预防效果 

分 类 号：R734.2[医药卫生—肿瘤]