血管内介入治疗与单纯药物治疗用于缺血性脑血管病的临床效果比较  

Comparison of the clinical effects of intravascular interventional therapy and simple drug therapy on ischemic cerebrovascular disease

作　　者：祖合热阿依.牙合甫[1] 党辉[1] 王成凤[1] 陈伟[2] Zuhereayi·yahefu;DANG Hui;WANG Chengfeng;CHEN Wei(Department of Neurology,the People′s Hospital of Xinjiang Autonomous Region,Xinjiang Uygur Autonomous Region,Urumqi 830000,China;Department of Neurosurgery,the First Affiliated Hospital of Xi′an Jiao Tong University,Shaanxi Province,Xi′an 710061,China)

机构地区：[1]新疆维吾尔自治区人民医院神经内科,新疆乌鲁木齐830000 [2]西安交通大学第一附属医院神经外科,陕西西安710061

出　　处：《中国医药导报》2018年第8期64-67,共4页China Medical Herald

基　　金：新疆维吾尔自治区自然科学基金资助项目(2013211B64)

摘　　要：目的探究血管内介入治疗与单纯药物治疗在缺血性脑血管病中的疗效差异。方法随机抽取2013年1月~2016年1月于新疆维吾尔自治区人民医院确诊为缺血性脑血管病(ICVD)的患者120例,将其随机分为观察组与对照组,每组各60例。观察组患者在给予药物治疗的基础上,再施行血管内介入治疗;对照组患者仅使用药物治疗。治疗1年后,对两组患者进行随访,分别评估两组患者的血液动力学改善情况、神经功能缺损评分(NIHSS)、血管狭窄程度变化和不良反应发生率。结果治疗1年后,观察组椎动脉、基底动脉、颈内动脉及颈总动脉收缩期峰流速中的治疗效果均显著优于对照组,差异有高度统计学意义(P<0.01);观察组NIHSS评分低于对照组,差异有高度统计学意义(P<0.01);治疗后观察组血管狭窄程度显著低于对照组,差异有高度统计学意义(P<0.01);且观察组不良发应发生率低于对照组,差异有统计学意义(P<0.05)。结论血管介入治疗在改善ICVD患者血液动力学情况、NIHSS评分、血管狭窄程度变化和不良反应发生率方面明显优于单纯药物治疗,值得在临床上推广。Objective To explore the clinical effect of endovascular treatment and simple drug treatment in the patients with ischemic cerebrovascular disease.Methods One hundred and twenty patients with ICVD in the People′s Hospital of Xinjiang Autonomous Region from January 2013 to January 2016 were randomly drawn,and they were randomly divided into the observation group and the control group,60 cases in each group.The patients in the observation group were treated with endovascular treatment on the basis of drug treatment,and the control group was only treated with single drugs treatment.One year later,patients of two groups were followed up.The hemodynamic improvement,NIHSS,degree of vascular stenosis and the incidence of adverse reactions were evaluated in two groups,respectively.Results After treatment for one year,the effect of the part of the vertebral artery,basilar artery,internal carotid artery and carotid artery peak systolic velocity in the observation group were better than that in the control group,the differences were statistically significant(P<0.01).The NIHSS of the observation group was lower than that in the control group,the difference was statistically significant(P<0.01).The degree of vascular stenosis after treatment was significantly lower than the control group,the difference was statistically significant(P<0.01).The incidence of adverse reaction in the observation group was also lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion Endovascular treatment is superior to simple drug therapy in terms of the hemodynamic improvement,NIHSS,vascular stenosis degree and incidence of adverse reactions in the treatment of ICVD,it is worthy of clinical promotion.

关 键 词：缺血性脑血管 血管内介入 单纯药物治疗 神经功能缺损评分 

分 类 号：R743.31[医药卫生—神经病学与精神病学]