盐酸埃克替尼对NSCLC患者血清PDCD5、P53及凋亡抑制蛋白Livin的影响  

Effect of Icitonib Hydrochloride on serum PDCD5,P53 and Livin in patients with NSCLC

作　　者：郭开峰[1] 缪继东[1] 郑成丽 杨丽丽 张鹏[2] GUO Kai-feng;MIAO Ji-dong;ZHENG Cheng-li(Department of Oncology,The Fourth People's Hospital of Zigong City,Zigong Sichuan 643000,China)

机构地区：[1]四川省自贡市第四人民医院肿瘤科,四川自贡643000 [2]江苏省南通市第一人民医院急诊科,江苏南通226001

出　　处：《临床和实验医学杂志》2018年第8期816-819,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨盐酸埃克替尼治疗非小细胞肺癌(NSCLC)的疗效及对患者血清程序性细胞凋亡因子5(PDCD5)、P53、Livin蛋白表达的影响。方法前瞻性选取确诊并治疗的98例NSCLC患者,收集时间2014年1月至2015年12月,随机分为两组,其中49例患者采用盐酸埃克替尼治疗(研究组),49例患者采用多西他赛、培美曲塞进行治疗(对照组)。化疗4个周期后进行临床效果评价,比较两组患者的临床疗效、不良反应和生存率情况。检测并比较两组患者治疗前后的血清PDCD5、P53、Livin蛋白。结果研究组的缓解率30.61%,总有效率79.59%,对照组的缓解率22.45%,总有效率67.35%,研究组略高于对照组,但差异均无统计学意义(P>0.05);治疗后,研究组的Livin蛋白水平低于对照组(P<0.05),PDCD5蛋白、P53蛋白均高于对照组(P<0.05);研究组患者Ⅱ~Ⅳ度的恶心呕吐、腹泻发生率显著低于对照组(P<0.05);两组患者均随访24个月,两组的1年生存率、2年生存率比较无统计学显著性(P>0.05)。结论盐酸埃克替尼治疗NSCLC患者的疗效与多西他赛、培美曲塞的效果基本一致,但其具有更有效的促进癌细胞凋亡作用,患者对其具有更好的耐受性。Objective To investigate the effect of icotinol hydrochloride in patients with non-small cell lung cancer(NSCLC)and its effect on serum PDCD5,P53,Livin protein expression.Methods A total of 98 patients with NSCLC diagnosed and treated in our hospital were selected from January 2014 to December 2015.49 patients were treated with imatinib hydrochloride(study group),49 patients received docetaxel,Pemetrexed for treatment(control group),4 cycles of chemotherapy for clinical evaluation.The clinical efficacy,adverse reactions and survival rates of the two groups were compared.The serum levels of PDCD5,P53 and Livin proteins before and after treatment were measured and compared between the two groups.Results The response rate of the study group was 30.61%,the total effective rate was 79.59%.The response rate of the control group was 22.45%,the total effective rate was 67.35%.The response rate of study group was slightly higher than that of the control group but the difference was not statistically significant(P>0.05).After treatment,the Livin protein level of the study group was lower than that of the control group(P<0.05),the PDCD5 and P53 protein were higher than those of the control group(P<0.05).Degree of II~Ⅳdegree of nausea and vomiting,diarrhea incidence was significantly lower than that of the control group(P<0.05).Two groups of patients were followed up for 24 months,1-year survival rate and 2-year survival rate in the two groups had no statistically significant difference(P>0.05).Conclusion The efficacy of imatinib hydrochloride in patients with NSCLC is consistent with the efficacy of docetaxel and pemetrexed,but it is more effective in promoting apoptosis of cancer cells and having better tolerance.

关 键 词：非小细胞肺癌 盐酸埃克替尼 LIVIN蛋白 PDCD5蛋白 P53蛋白 

分 类 号：R734.2[医药卫生—肿瘤]