miRNA与子宫内膜癌的相关性及临床应用可能性的研究进展  

Research Progress of Correlation between the miRNA and Endometrial Carcinoma and Clinical Probability

作　　者：赵婉 张颖[1] ZHAO Wan;ZHANG Ying(Department of Pathology,Zhuhai Maternal and Child Healthcare Hospital,Zhuhai,Guangdong Province,519000 China)

机构地区：[1]珠海市妇幼保健院病理科,广东珠海519000

出　　处：《世界复合医学》2018年第1期96-98,共3页World Journal of Complex Medicine

摘　　要：子宫内膜癌是常见的妇科恶性肿瘤,但是目前仍缺乏可用于早期诊断的特异性生物标记物,并且少有效果优于手术的治疗方法。miRNA是一种内源性非编码RNA,通过调控转录后水平基因的表达实现对机体的调节功能。近年来研究发现多种miRNA在子宫内膜癌中表达异常,miRNA有望成为子宫内膜癌诊断、判断预后及治疗的新靶点。该文就miRNA与子宫内膜癌的发病机制、诊断、治疗等方面的研究进展做一简要综述。The endometrial carcinoma is the common gynecological malignant tumors,but the special biochemical markers used in the early diagnosis are still insufficient,and the effect is worse than that of surgery,miRNA is a kind of endogenous non-code RNA,realizing the adjustment of body by the expression of gene levels,in recent years,the expression of multiple miRNA in the endometrial carcinoma is abnormal,and the miRNA is likely to be the new target point of diagnosis of endometrial carcinoma,determining the prognosis and treatment.The paper briefly elaborates the research progress of onset mechanism,diagnosis and treatment of miRNA and endometrial carcinoma.

关 键 词：MIRNA 子宫内膜癌 生物标记物 

分 类 号：R737.23[医药卫生—肿瘤]