阿司匹林联合氯吡格雷治疗高危非致残性脑血管病的临床研究  

Clinical research of aspirin associated with clopidogrel in treating acute non-disabling cerebrovascular disease

作　　者：邱茜茜[1] 孙巧丽[1] 范波胜[1] QIU Xixi;SUN Qiaoli;FAN Bosheng(Department of Neurology,Central Hospital of Jiaozuo Coal Industry Group,Jiaozuo 454000,China)

机构地区：[1]焦作煤业集团中央医院神经内科,河南焦作454150

出　　处：《中国实用神经疾病杂志》2018年第8期827-829,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察阿司匹林联合氯吡格雷的治疗组与单用阿司匹林的对照组降低高危非致残性脑血管病患者90d内发生缺血性卒中风险的效果及安全性。方法将符合标准的100例高危非致残性脑血管病患者随机分为治疗组和对照组各50例,对照组仅给予阿司匹林治疗,治疗组给予阿司匹林联合氯吡格雷治疗,观察2组患者90d内发生主要终点事件及次要终点事件的情况,并在21d比较2组患者血液学指标(PT、APTT、FIB)变化情况及用药期间出血等不良反应发生情况。结果对照组发生主要终点事件7例(14%),次要终点事件2例(4%);治疗组发生主要终点事件3例(6%),次要终点事件2例(4%),2组主要终点事件比较差异具有统计学意义(P<0.05),次要终点事件差异无统计学意义(P>0.05);在治疗21d时,治疗组PT、APTT高于对照组,差异有统计学意义(P<0.05),而FIB低于对照组,差异有统计学意义(P<0.05),比较治疗期间2组间不良反应的发生率差异无统计学意义(P>0.05)。结论阿司匹林联合氯吡格雷治疗组比单用阿司匹林对照组能够有效减少主要终点事件发生率,并能改善血液学指标,但不增加不良反应发生,值得推广应用。Objective To investigate the effect and safety of aspirin and clopidogrel in treating acute non disabling cerebrovascular events.Methods 100 patients with acute non disabling cerebrovascular events were enrolled in this study and randomly divided into two groups,the control group and treatment group.The control group was treated with only aspirin,and treatment group was treated with clopidogrel and aspirin.The primary and secondary outcome were observed within 90 days.Differences of hematologicalindex(PT、APTT、FIB)21 days after treatment and safety between two groups were compared.Results In the treatmentgroup,3(6%)patients experienced primary outcome and 2(4%)experienced secondary outcome compared with7(14%)and 2(4%)of patients treated with aspirin.There was asignificant difference in the primary outcome(P<0.05),but no significant difference in secondary outcome and safety(P>0.05).There were obvious differences in hematological index(PT、APTT、FIB)21 days after treatment between two groups(P<0.05).Conclusion Aspirin and clopidogrel are safe and effective on the treatment of acute non disabling cerebrovascular events.

关 键 词：氯吡格雷 阿司匹林 高危非致残性脑血管病 血液学指标 主要终点事件 

分 类 号：R743.31[医药卫生—神经病学与精神病学]