普拉克索对帕金森病运动障碍的影响  

Effect of pramipexole ondyskinesia in Parkinson's disease

作　　者：胡颖[1] HU Ying(Department of Neurology,Peixian County People's Hospital,Peixian 221600,China)

机构地区：[1]沛县人民医院神经内科,江苏沛县221600

出　　处：《中国实用神经疾病杂志》2018年第8期898-900,共3页Chinese Journal of Practical Nervous Diseases

基　　金：国家自然科学基金青年项目;编号:81201025;江苏省自然科学基金面上项目;编号:BK20131118

摘　　要：目的分析普拉克索对治疗帕金森病运动障碍的临床疗效。方法选择我院收治的60例帕金森病患者为研究对象,随机数字表分为对照组(30例)与观察组(30例),对照组予以左旋多巴、司来吉兰等常规治疗药,观察组在对照组治疗基础上加用盐酸普拉克索,2组患者均治疗8周,治疗后采用帕金森评定量表(UPDRS)Ⅱ、Ⅲ及总体评分量表评价运动功能,并判断疗效。结果治疗前比较,2组UPDRSⅡ、UPDRSⅢ及总评分均差异无统计学意义(P>0.05);治疗后,2组各量表评分较治疗前均显著下降,且观察组下降幅度明显高于对照组,组间差异均具有统计学意义(P<0.05);对照组总不良反应发生率23.3%,观察组13.3%,差异无统计学意义(P>0.05)。结论普拉克索可作为治疗帕金森病患者的加强药,在左旋多巴、司来吉兰等药物基础治疗上,可显著增强其治疗疗效,缓解运动症状障碍,且具有较高的安全性,值得临床推广。Objective To analyze the clinical curative effect of pramipexole in the treatment of dyskinesia in Parkinson's disease(PD).Methods 60 patients with PD in our hospital were selected as the subjects,and they were divided into the control group(30 cases)and the observation group(30 cases)by the random number table method.The control group was treated with levodopa and selegiline and other conventional treatment.On the basis,the observation group was additionally treated with pramipexole hydrochloride.The 2 groups of patients were treated for 8 weeks.After treatment,the motor function was evaluated with the Unified Parkinson's Disease Rating Scale(UPDRS)II,III and the total rating scale,and the curative effect was also evaluated.Results Before treatment,there was no significant difference between the 2 groups in scores of UPDRS II and UPDRS III and the total score(P>0.05).After treatment,the scores of the 2 groups were significantly decreased,and the decrease in observation group was significantly greater than that in the control group(P<0.05).There was no significant difference between the 2 groups in the total incidence of adverse reactions(23.3%vs 13.3%)(P>0.05).Conclusion Pulakesuoke combined with levodopa and selegiline can significantly enhance the curative effect and relieve the symptoms of dyskinesia,with high safety.

关 键 词：普拉克索 帕金森病 运动障碍 临床疗效 震颤性麻痹 

分 类 号：R742.5[医药卫生—神经病学与精神病学]