抗幽门螺旋杆菌治疗对内镜下粘膜切除术后溃疡愈合的作用  

Effect of Anti-Helicobacter Pylori Treatment on Ulcer Healing after the Endoscopic Mucosal Resection

作　　者：洪丽霞 HONG Li-xia(Digestive System Department,Putian Hanjiang Hospital,Putian,Fujian Province,351111 China)

机构地区：[1]福建省莆田市涵江医院消化内科,福建莆田351111

出　　处：《中外医疗》2017年第35期84-86,共3页China & Foreign Medical Treatment

摘　　要：目的判断根除幽门螺杆菌(Hp)对内镜下黏膜切除术(EMR)后溃疡愈合效果的观察。方法方便选取80例2015年6月—2017年5月期间该院胃粘膜息肉合并有HP感染患者纳入研究,将80例患者随机按随机数字分为两组,HP根除组和安慰剂组各40例,分别于术后1、2、4周复查内镜。观察创面愈合情况。结果 EMR术后1周,根除幽门螺杆菌组和安慰剂组的溃疡分期为活动期分别为10例和32例,根除幽门螺杆菌组分期显著优于安慰剂组。差异有统计学意义(P<0.05)。术后2周胃镜根除幽门螺杆菌组和安慰剂组在活动期为0例和14例,愈合期分别为10例和8例,差异无统计学意义(P>0.05)。术后4周,根除幽门螺杆菌组和安慰剂组在疤痕期分别为40例和32例,安慰剂组还有8例在愈合期。但差异无统计学意义(P>0.05)。结论抗幽门螺旋杆菌治疗可以有效帮助EMR术后创面的愈合,显著提高病灶的愈合率。Objective To determine and observe the effect of anti-Helicobacter pylori treatment on ulcer healing after the endoscopic mucosal resection.Methods 80 cases of patients with gastric mucosa polyps combined with HP infection in our hospital from June 2015 to May 2017 were convenient selected and randomly divided into two groups with 40 cases in each,including the HP eradication group and placebo group,and the endoscope was reexamined in 1-week,2-week and 4-week after operation,and the wound healing was observed.Results 10 cases and 32 cases were respectively in the active stage in the HP group and in the placebo group in 1 week after EMR surgery,which showed that the staging in the HP group was obviously better than that in the placebo group,and the difference was statistically significant(P<0.05),and 0 case and 14 cases were respectively in the active stage and 10 cases and 8 cases were in the healing stage in the HP group and placebo group in the 2 weeks after surgery,and the differences were not statistically significant(P>0.05),and 40 cases and 32 cases were respectively in the scar stage in the HP group and in the placebo group in 4 weeks after surgery,and there were 8 cases in the healing stage in the placebo group,but the difference was not statistically significant(P>0.05).Conclusion The anti-Helicobacter pylori treatment can effectively help the healing of wound after the EMR surgery and obviously improve the healing rate of lesions.

关 键 词：胃镜下粘膜切除术(EMR) 粘膜切除术后溃疡 幽门螺杆菌(Hp) 

分 类 号：R57[医药卫生—消化系统]