骨髓间充质干细胞向肝细胞分化的相关细胞因子及信号通路的研究进展  

Current studies on cytokines and signal pathways involved in bone marrow mesenchymal stem cells differentiation into hepatocytes cells

作　　者：陈嘉成 傅念[1] 黄幼姣 全宏军 Chen Jiacheng;Fu Nian;Huang Youjiao;Quan Hongjun(Department of Gastroenterology,Affiliated Nanhua Hospital,University of South China,Hengyang 421002,China)

机构地区：[1]南华大学附属南华医院消化内科,衡阳421002

出　　处：《中华细胞与干细胞杂志（电子版）》2018年第1期59-62,共4页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：湖南省自然科学基金(2016JJ3107)

摘　　要：骨髓干细胞包括造血干细胞(HSCs)和间充质干细胞(MSCs),骨髓间充质干细胞(BMSCs)是一类具有自我更新、增殖和多向分化能力的细胞,具有不对称分裂和无限增殖的特点。在肝细胞生长因子(HGF)的作用下,BMSCs可以分化为肝细胞,参与诱导这一分化过程的相关信号通路包括NF-k B信号通路、Notch信号通路、MAPK信号通路、Wnt信号通路和STAT3信号通路。文章主要就BMSCs分化为肝细胞的相关信号通路进行了综述。Bone marrow stem cells include hematopoietic stem cells and mesenchymal stem cells.Bone marrow mesenchymal stem cells(BMSCs)are a kind of cells with properties of selfrenewal,proliferation and multi-directional differentiation,and have the characteristic of asymmetric cell division and unlimited proliferation.Under the influences of hepatocyte growth factor(HGF),BMSCs can differentiate into liver cells,and related signaling pathways involved in the differentiation process include NF-kB signal pathways,Notch signal pathways,MAPK signal pathways,Wnt signal pathways and STAT3 signal pathways.The related signaling pathways of BMSCs differentiation into hepatocytes are reviewed in this article.

关 键 词：骨髓间充质干细胞 肝样细胞 信号通路 分化 

分 类 号：R575[医药卫生—消化系统]