胶囊内镜在非甾体抗炎药相关小肠粘膜损害中的临床意义  

Clinical Significance of Capsule Endoscopy in Non-steroidal Anti-inflammatory Drug-related Intestinal Mucosal Injury

作　　者：段雪辉[1] 尹合坤[1] 谭燕萌 吴伟东[1] DUAN Xue-hui;YIN He-kun;TAN Yan-men;WU Wei-dong(Dept.of Gastroenterology,Jiangmen Central Hospital,Jiangmen,Guangdong 529030)

机构地区：[1]江门市中心医院消化内科,广东江门529030

出　　处：《赣南医学院学报》2018年第3期222-224,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江门市科学技术局科技计划项目(江科【2014】71号-39)

摘　　要：目的:分析胶囊内镜观察下阿司匹林引起小肠粘膜损伤中的特点。方法:根据有无服用阿司匹林患者分为观察组132例,对照组76例;观察患者服用阿司匹林不同时间小肠粘膜损伤的差异及不同组间小肠粘膜损伤程度的差异。结果:对照组消化症状发生率低于观察组,差异有统计学意义(P=0.000);对照组腹泻、腹痛及消化道出血症状低于观察组,差异有统计学意义(P均<0.05);观察组患者粘膜出血率、水肿率明显高于对照组,差异有统计学意义(P均<0.05);服药持续时间>1个月的患者小肠粘膜损伤发生率(75.9%)明显高于持续时间<1个月患者(57.7%),差异有统计学意义(P=0.038)。结论:未服阿司匹林组中小肠粘膜损伤发生率明显低于服阿司匹林组,且随服用阿司匹林时间延长,小肠粘膜损伤发生率升高;胶囊内镜是小肠无创检查,在阿司匹林相关小肠粘膜损伤中发挥重要的诊断价值。Objective:To explore the features of Aspirin induced small intestinal mucosal injury under capsule endoscope.Methods:The patients were divided into observation group(n=132)and control group(n=76)according to whether they took aspirin or not,The differences and the degree of intestinal mucosal injury at different time and in different groups were compared under capsule endoscopy.Results:The incidence of digestive tract symptoms in the control group was significantly lower than that in the observation group;the difference was statistically significant(χ2=19.070,P=0.000).The symptoms of diarrhea,abdominal pain and digestive tract bleeding in the control group were significantly lower than thoset in the observation group;the difference was statistically significant(χ2=4.320,4.870,7.192;P<0.05).The rate of mucosal hemorrhage and edema in the observation group was significantly higher than that in the control group(χ2=6.920、4.931,P<0.05).The incidence of intestinal mucosal damage was significantly higher in patients with the medication duration>1 months(75.9%,41/54)than in the patients whose medication duration<1 months(57.7%,45/78);the difference was statistically significant(χ2=4.302,P=0.038).Conclusion:The incidence of small intestinal mucosal injury was significantly lower in the group with aspirin,and the incidence increased significantly with the duration of the drug;Capsule endoscopy is a non-invasive examination of small intestine,and plays an important diagnostic value in the aspirin-related small intestinal mucosal injury.

关 键 词：胶囊内镜 消炎药 非甾类 阿司匹林 小肠粘膜损伤 

分 类 号：R574.5[医药卫生—消化系统]